New insights into leukocyte recruitment by intravital microscopy

Alexander Zarbock, Klaus Ley

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations


Leukocyte recruitment to sites of inflammation requires adhesion to and transmigration through the blood vessel wall. Recent progress in optical equipment and new genetic and molecular tools have revealed additional steps in the leukocyte adhesion cascade beyond rolling, adhesion, and transmigration. In vivo studies using intravital microscopy (IVM) were essential for the discovery of slow rolling, postadhesion strengthing, intraluminal crawling, and different routes of transmigration. IVM revealed unique features of leukocyte recruitment in different organs. This review focuses on insights into the leukocyte adhesion cascade gained by IVM.

Original languageEnglish (US)
Title of host publicationVisualizing Immunity
PublisherSpringer Verlag
Number of pages24
ISBN (Print)9783540938620
StatePublished - 2009
Externally publishedYes

Publication series

NameCurrent Topics in Microbiology and Immunology
ISSN (Print)0070-217X

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)


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