Niacin modulates macrophage polarization in Parkinson's disease

Chandramohan Wakade, Banabihari Giri, Aneeq Malik, Hesam Khodadadi, John C. Morgan, Raymond K. Chong, Babak Baban

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression.

Original languageEnglish (US)
Pages (from-to)76-79
Number of pages4
JournalJournal of Neuroimmunology
StatePublished - Jul 15 2018


  • GPR109A
  • Macrophage polarization
  • Niacin
  • Parkinson's disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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