TY - JOUR
T1 - NIAID, NIEHS, NHLBI, and MCAN Workshop Report
T2 - The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management
AU - Gold, Diane R.
AU - Adamkiewicz, Gary
AU - Arshad, Syed Hasan
AU - Celedón, Juan C.
AU - Chapman, Martin D.
AU - Chew, Ginger L.
AU - Cook, Donald N.
AU - Custovic, Adnan
AU - Gehring, Ulrike
AU - Gern, James E.
AU - Johnson, Christine C.
AU - Kennedy, Suzanne
AU - Koutrakis, Petros
AU - Leaderer, Brian
AU - Mitchell, Herman
AU - Litonjua, Augusto A.
AU - Mueller, Geoffrey A.
AU - O'Connor, George T.
AU - Ownby, Dennis Randall
AU - Phipatanakul, Wanda
AU - Persky, Victoria
AU - Perzanowski, Matthew S.
AU - Ramsey, Clare D.
AU - Salo, Päivi M.
AU - Schwaninger, Julie M.
AU - Sordillo, Joanne E.
AU - Spira, Avrum
AU - Suglia, Shakira F.
AU - Togias, Alkis
AU - Zeldin, Darryl C.
AU - Matsui, Elizabeth C.
N1 - Publisher Copyright:
© 2017
PY - 2017/10
Y1 - 2017/10
N2 - Environmental exposures have been recognized as critical in the initiation and exacerbation of asthma, one of the most common chronic childhood diseases. The National Institute of Allergy and Infectious Diseases; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; and Merck Childhood Asthma Network sponsored a joint workshop to discuss the current state of science with respect to the indoor environment and its effects on the development and morbidity of childhood asthma. The workshop included US and international experts with backgrounds in allergy/allergens, immunology, asthma, environmental health, environmental exposures and pollutants, epidemiology, public health, and bioinformatics. Workshop participants provided new insights into the biologic properties of indoor exposures, indoor exposure assessment, and exposure reduction techniques. This informed a primary focus of the workshop: to critically review trials and research relevant to the prevention or control of asthma through environmental intervention. The participants identified important limitations and gaps in scientific methodologies and knowledge and proposed and prioritized areas for future research. The group reviewed socioeconomic and structural challenges to changing environmental exposure and offered recommendations for creative study design to overcome these challenges in trials to improve asthma management. The recommendations of this workshop can serve as guidance for future research in the study of the indoor environment and on environmental interventions as they pertain to the prevention and management of asthma and airway allergies.
AB - Environmental exposures have been recognized as critical in the initiation and exacerbation of asthma, one of the most common chronic childhood diseases. The National Institute of Allergy and Infectious Diseases; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; and Merck Childhood Asthma Network sponsored a joint workshop to discuss the current state of science with respect to the indoor environment and its effects on the development and morbidity of childhood asthma. The workshop included US and international experts with backgrounds in allergy/allergens, immunology, asthma, environmental health, environmental exposures and pollutants, epidemiology, public health, and bioinformatics. Workshop participants provided new insights into the biologic properties of indoor exposures, indoor exposure assessment, and exposure reduction techniques. This informed a primary focus of the workshop: to critically review trials and research relevant to the prevention or control of asthma through environmental intervention. The participants identified important limitations and gaps in scientific methodologies and knowledge and proposed and prioritized areas for future research. The group reviewed socioeconomic and structural challenges to changing environmental exposure and offered recommendations for creative study design to overcome these challenges in trials to improve asthma management. The recommendations of this workshop can serve as guidance for future research in the study of the indoor environment and on environmental interventions as they pertain to the prevention and management of asthma and airway allergies.
KW - Asthma
KW - allergy
KW - child health
KW - clinical trials
KW - environmental intervention
KW - indoor allergens
KW - pollutants
UR - http://www.scopus.com/inward/record.url?scp=85020390434&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020390434&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2017.04.024
DO - 10.1016/j.jaci.2017.04.024
M3 - Article
C2 - 28502823
AN - SCOPUS:85020390434
SN - 0091-6749
VL - 140
SP - 933
EP - 949
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 4
ER -