TY - JOUR
T1 - Nonspherical Metal-Based Nanoarchitectures
T2 - Synthesis and Impact of Size, Shape, and Composition on Their Biological Activity
AU - Zare, Ehsan Nazarzadeh
AU - Zheng, Xuanqi
AU - Makvandi, Pooyan
AU - Gheybi, Homa
AU - Sartorius, Rossella
AU - Yiu, Cynthia K.Y.
AU - Adeli, Mohsen
AU - Wu, Aimin
AU - Zarrabi, Ali
AU - Varma, Rajender S.
AU - Tay, Franklin R.
N1 - Publisher Copyright:
© 2021 Wiley-VCH GmbH
PY - 2021/4/28
Y1 - 2021/4/28
N2 - Metal-based nanoentities, apart from being indispensable research tools, have found extensive use in the industrial and biomedical arena. Because their biological impacts are governed by factors such as size, shape, and composition, such issues must be taken into account when these materials are incorporated into multi-component ensembles for clinical applications. The size and shape (rods, wires, sheets, tubes, and cages) of metallic nanostructures influence cell viability by virtue of their varied geometry and physicochemical interactions with mammalian cell membranes. The anisotropic properties of nonspherical metal-based nanoarchitectures render them exciting candidates for biomedical applications. Here, the size-, shape-, and composition-dependent properties of nonspherical metal-based nanoarchitectures are reviewed in the context of their potential applications in cancer diagnostics and therapeutics, as well as, in regenerative medicine. Strategies for the synthesis of nonspherical metal-based nanoarchitectures and their cytotoxicity and immunological profiles are also comprehensively appraised.
AB - Metal-based nanoentities, apart from being indispensable research tools, have found extensive use in the industrial and biomedical arena. Because their biological impacts are governed by factors such as size, shape, and composition, such issues must be taken into account when these materials are incorporated into multi-component ensembles for clinical applications. The size and shape (rods, wires, sheets, tubes, and cages) of metallic nanostructures influence cell viability by virtue of their varied geometry and physicochemical interactions with mammalian cell membranes. The anisotropic properties of nonspherical metal-based nanoarchitectures render them exciting candidates for biomedical applications. Here, the size-, shape-, and composition-dependent properties of nonspherical metal-based nanoarchitectures are reviewed in the context of their potential applications in cancer diagnostics and therapeutics, as well as, in regenerative medicine. Strategies for the synthesis of nonspherical metal-based nanoarchitectures and their cytotoxicity and immunological profiles are also comprehensively appraised.
KW - biological activity
KW - immune response
KW - metal-based nanoarchitectures
KW - nonspherical nanoparticles
KW - organ toxicity
UR - http://www.scopus.com/inward/record.url?scp=85102393118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102393118&partnerID=8YFLogxK
U2 - 10.1002/smll.202007073
DO - 10.1002/smll.202007073
M3 - Review article
C2 - 33710754
AN - SCOPUS:85102393118
SN - 1613-6810
VL - 17
JO - Small
JF - Small
IS - 17
M1 - 2007073
ER -