Novel mechanisms of endothelial dysfunction in diabetes

Guang Yang; Rudolf Lucas; Ruth Caldwell; Lin Yao; Maritza Romero; Robert Caldwell

doi:10.4103/0975-3583.64432

Novel mechanisms of endothelial dysfunction in diabetes

Guang Yang, Rudolf Lucas, Ruth Caldwell, Lin Yao, Maritza Romero, Robert Caldwell

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Diabetes mellitus is a major risk factor for cardiovascular morbidity and mortality. This condition increases the risk of developing coronary, cerebrovascular, and peripheral arterial disease fourfold. Endothelial dysfunction is a major contributor to the pathogenesis of vascular disease in diabetes mellitus patients and has recently received increased attention. In this review article, some recent developments that could improve the knowledge of diabetes-induced endothelial dysfunction are discussed.

Original language	English (US)
Pages (from-to)	59-63
Number of pages	5
Journal	Journal of Cardiovascular Disease Research
Volume	1
Issue number	2
DOIs	https://doi.org/10.4103/0975-3583.64432
State	Published - 2010

Keywords

Arginase
diabetes
endothelial dysfunction
protein kinase C
reactive oxygen species
tumor necrosis factor

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4103/0975-3583.64432

Cite this

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AU - Yang, Guang

AU - Lucas, Rudolf

AU - Caldwell, Ruth

AU - Yao, Lin

AU - Romero, Maritza

AU - Caldwell, Robert

PY - 2010

Y1 - 2010

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AB - Diabetes mellitus is a major risk factor for cardiovascular morbidity and mortality. This condition increases the risk of developing coronary, cerebrovascular, and peripheral arterial disease fourfold. Endothelial dysfunction is a major contributor to the pathogenesis of vascular disease in diabetes mellitus patients and has recently received increased attention. In this review article, some recent developments that could improve the knowledge of diabetes-induced endothelial dysfunction are discussed.

KW - Arginase

KW - diabetes

KW - endothelial dysfunction

KW - protein kinase C

KW - reactive oxygen species

KW - tumor necrosis factor

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Novel mechanisms of endothelial dysfunction in diabetes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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