Old and new roles and evolving complexities of cardiovascular clocks

Yanyan Xu, Wenhu Pi, Radu Daniel Rudic

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


The cardiovascular (CV†) system has been established to be significantly influenced by the molecular components of circadian rhythm. Oscillations of circadian rhythm occur within the circulation to affect thrombosis and blood pressure and within CV tissues including arteries, heart, and kidney to control function. Physiologic and molecular oscillations of circadian rhythm have been well connected via global, tissue-specific, and transgenic reporter mouse models of key core clock signals such as Bmal1, Period, and Clock, which can produce both pathology and protection with their mutation. With different nuances of CV clock action continuing to emerge in studies of the cardiovascular system, new questions are raised in both new and old mouse model system observations that underscore the importance, complexity, and continued study of the circadian clock mechanism in cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalYale Journal of Biology and Medicine
Issue number2
StatePublished - 2019


  • Blood pressure
  • Bmal1
  • Cardiovascular
  • Circadian
  • Clock

ASJC Scopus subject areas

  • Medicine(all)


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