TY - JOUR
T1 - Opening the flood-gates
T2 - how neutrophil-endothelial interactions regulate permeability
AU - DiStasi, Matthew R.
AU - Ley, Klaus
PY - 2009/11
Y1 - 2009/11
N2 - Many diseases have an inflammatory component, where neutrophil interactions with the vascular endothelium lead to barrier dysfunction and increased permeability. Neutrophils increase permeability through secreted products such as the chemokines CXCL1, 2, 3, and 8, through adhesion-dependent processes involving β2 integrins interacting with endothelial ICAM-1, and through combinations where β2 integrin engagement leads to degranulation and secretion of heparin-binding protein. Some neutrophil products, such as arachidonic acid or the leukotriene LTA4, are further processed by endothelial enzymes via transcellular metabolism before the resulting products thromboxane A2 or LTC4 can activate their cognate receptors. Neutrophils also generate reactive oxygen species that induce vascular leakage. This review focuses on the mechanisms of neutrophil-mediated leakage.
AB - Many diseases have an inflammatory component, where neutrophil interactions with the vascular endothelium lead to barrier dysfunction and increased permeability. Neutrophils increase permeability through secreted products such as the chemokines CXCL1, 2, 3, and 8, through adhesion-dependent processes involving β2 integrins interacting with endothelial ICAM-1, and through combinations where β2 integrin engagement leads to degranulation and secretion of heparin-binding protein. Some neutrophil products, such as arachidonic acid or the leukotriene LTA4, are further processed by endothelial enzymes via transcellular metabolism before the resulting products thromboxane A2 or LTC4 can activate their cognate receptors. Neutrophils also generate reactive oxygen species that induce vascular leakage. This review focuses on the mechanisms of neutrophil-mediated leakage.
UR - http://www.scopus.com/inward/record.url?scp=70350029795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350029795&partnerID=8YFLogxK
U2 - 10.1016/j.it.2009.07.012
DO - 10.1016/j.it.2009.07.012
M3 - Review article
C2 - 19783480
AN - SCOPUS:70350029795
SN - 1471-4906
VL - 30
SP - 547
EP - 556
JO - Trends in Immunology
JF - Trends in Immunology
IS - 11
ER -