TY - JOUR
T1 - Oxidative Stress and the Development of Endothelial Dysfunction in Congenital Heart Disease With Increased Pulmonary Blood Flow
T2 - Lessons From the Neonatal Lamb
AU - Aggarwal, Saurabh
AU - Gross, Christine
AU - Fineman, Jeffrey R.
AU - Black, Stephen M.
N1 - Funding Information:
This research was supported in part by grants HL60190 (SMB), HL67841 (SMB), HL084739 (SMB), R21HD057406 (SMB), and HL61284 (JRF) from the National Institutes of Health and by a grant from the Fondation Leducq (SMB and JRF). SA was supported in part by an American Heart Association pre-doctoral fellowship, and CG is supported by 5T32HL076146.
PY - 2010/10
Y1 - 2010/10
N2 - Congenital heart diseases associated with increased pulmonary blood flow commonly leads to the development of pulmonary hypertension. However, most patients who undergo histological evaluation have advanced pulmonary hypertension, and therefore it has been difficult to investigate aberrations in signaling cascades that precede the development of overt vascular remodeling. This review discusses the role played by both oxidative and nitrosative stress in the lung and their impact on the signaling pathways that regulate vasodilation, vessel growth, and vascular remodeling in the neonatal lung exposed to increased pulmonary blood flow.
AB - Congenital heart diseases associated with increased pulmonary blood flow commonly leads to the development of pulmonary hypertension. However, most patients who undergo histological evaluation have advanced pulmonary hypertension, and therefore it has been difficult to investigate aberrations in signaling cascades that precede the development of overt vascular remodeling. This review discusses the role played by both oxidative and nitrosative stress in the lung and their impact on the signaling pathways that regulate vasodilation, vessel growth, and vascular remodeling in the neonatal lung exposed to increased pulmonary blood flow.
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U2 - 10.1016/j.tcm.2011.11.010
DO - 10.1016/j.tcm.2011.11.010
M3 - Review article
C2 - 22293025
AN - SCOPUS:84856328489
SN - 1050-1738
VL - 20
SP - 238
EP - 246
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 7
ER -