Oxygen, free radicals, and the kidney

Paul M O'Connor; Carlos M. Schreck; Roger G. Evans

doi:10.1007/978-3-642-30018-9_112

Oxygen, free radicals, and the kidney

Paul M O'Connor, Carlos M. Schreck, Roger G. Evans

Physiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

The kidneys are unique in that oxygen delivery far outweighs metabolic demand. As a result, renal O₂ extraction is normally low (∼15 % compared with ∼35-40 % in most tissues), and tissue O₂ tension is relatively high, particularly within the highly perfused renal cortical region. Reactive oxygen species play an important role in normal cellular function, and excess production of reactive oxygen species (oxidative stress) can lead to the development of disease. It is well established that the rate of production of reactive oxygen species varies with O₂ tension. In this chapter, we review the known molecular sources of reactive oxygen species within the kidney and their dependence on O₂ tension. Included in this discussion, we will review the unique physiology of the kidney and how this affects renal O₂ tension and the production of reactive oxygen species. We will also review the pathophysiological relationship between the development of renal hypoxia and production of reactive oxygen species within the kidney.

Original language	English (US)
Title of host publication	Systems Biology of Free Radicals and Antioxidants
Publisher	Springer-Verlag Berlin Heidelberg
Pages	2563-2580
Number of pages	18
ISBN (Electronic)	9783642300189
ISBN (Print)	3642300170, 9783642300172
DOIs	https://doi.org/10.1007/978-3-642-30018-9_112
State	Published - May 1 2012

Keywords

Hydrogen peroxide
Modeling
Reactive oxygen species
Renal
Superoxide

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-642-30018-9_112

Cite this

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abstract = "The kidneys are unique in that oxygen delivery far outweighs metabolic demand. As a result, renal O2 extraction is normally low (∼15 % compared with ∼35-40 % in most tissues), and tissue O2 tension is relatively high, particularly within the highly perfused renal cortical region. Reactive oxygen species play an important role in normal cellular function, and excess production of reactive oxygen species (oxidative stress) can lead to the development of disease. It is well established that the rate of production of reactive oxygen species varies with O2 tension. In this chapter, we review the known molecular sources of reactive oxygen species within the kidney and their dependence on O2 tension. Included in this discussion, we will review the unique physiology of the kidney and how this affects renal O2 tension and the production of reactive oxygen species. We will also review the pathophysiological relationship between the development of renal hypoxia and production of reactive oxygen species within the kidney.",

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AU - O'Connor, Paul M

AU - Schreck, Carlos M.

AU - Evans, Roger G.

N1 - Publisher Copyright: © Springer-Verlag Berlin Heidelberg 2014. All rights are reserved.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - The kidneys are unique in that oxygen delivery far outweighs metabolic demand. As a result, renal O2 extraction is normally low (∼15 % compared with ∼35-40 % in most tissues), and tissue O2 tension is relatively high, particularly within the highly perfused renal cortical region. Reactive oxygen species play an important role in normal cellular function, and excess production of reactive oxygen species (oxidative stress) can lead to the development of disease. It is well established that the rate of production of reactive oxygen species varies with O2 tension. In this chapter, we review the known molecular sources of reactive oxygen species within the kidney and their dependence on O2 tension. Included in this discussion, we will review the unique physiology of the kidney and how this affects renal O2 tension and the production of reactive oxygen species. We will also review the pathophysiological relationship between the development of renal hypoxia and production of reactive oxygen species within the kidney.

AB - The kidneys are unique in that oxygen delivery far outweighs metabolic demand. As a result, renal O2 extraction is normally low (∼15 % compared with ∼35-40 % in most tissues), and tissue O2 tension is relatively high, particularly within the highly perfused renal cortical region. Reactive oxygen species play an important role in normal cellular function, and excess production of reactive oxygen species (oxidative stress) can lead to the development of disease. It is well established that the rate of production of reactive oxygen species varies with O2 tension. In this chapter, we review the known molecular sources of reactive oxygen species within the kidney and their dependence on O2 tension. Included in this discussion, we will review the unique physiology of the kidney and how this affects renal O2 tension and the production of reactive oxygen species. We will also review the pathophysiological relationship between the development of renal hypoxia and production of reactive oxygen species within the kidney.

KW - Hydrogen peroxide

KW - Modeling

KW - Reactive oxygen species

KW - Renal

KW - Superoxide

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BT - Systems Biology of Free Radicals and Antioxidants

PB - Springer-Verlag Berlin Heidelberg

ER -

Oxygen, free radicals, and the kidney

Abstract

Keywords

ASJC Scopus subject areas

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