p16 and ARF: Activation of teenage proteins in old age

Ande Satyanarayana, Karl Lenhard Rudolph

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus - p16INK4a and ARF - arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging (see the related article beginning on page 1299).

Original languageEnglish (US)
Pages (from-to)1237-1240
Number of pages4
JournalJournal of Clinical Investigation
Issue number9
StatePublished - Nov 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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