p16 and ARF: Activation of teenage proteins in old age

Ande Satyanarayana; Karl Lenhard Rudolph

doi:10.1172/JCI23437

p16 and ARF: Activation of teenage proteins in old age

Ande Satyanarayana, Karl Lenhard Rudolph

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus - p16^INK4a and ARF - arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging (see the related article beginning on page 1299).

Original language	English (US)
Pages (from-to)	1237-1240
Number of pages	4
Journal	Journal of Clinical Investigation
Volume	114
Issue number	9
DOIs	https://doi.org/10.1172/JCI23437
State	Published - Nov 2004
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1172/JCI23437

Cite this

@article{b9145f34d9dc4fef8049263eabdcbb45,

title = "p16 and ARF: Activation of teenage proteins in old age",

abstract = "Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus - p16INK4a and ARF - arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging (see the related article beginning on page 1299).",

author = "Ande Satyanarayana and Rudolph, {Karl Lenhard}",

year = "2004",

month = nov,

doi = "10.1172/JCI23437",

language = "English (US)",

volume = "114",

pages = "1237--1240",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "The American Society for Clinical Investigation",

number = "9",

}

TY - JOUR

T1 - p16 and ARF

T2 - Activation of teenage proteins in old age

AU - Satyanarayana, Ande

AU - Rudolph, Karl Lenhard

PY - 2004/11

Y1 - 2004/11

N2 - Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus - p16INK4a and ARF - arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging (see the related article beginning on page 1299).

AB - Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus - p16INK4a and ARF - arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging (see the related article beginning on page 1299).

UR - http://www.scopus.com/inward/record.url?scp=84889466595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84889466595&partnerID=8YFLogxK

U2 - 10.1172/JCI23437

DO - 10.1172/JCI23437

M3 - Review article

C2 - 15520854

AN - SCOPUS:84889466595

SN - 0021-9738

VL - 114

SP - 1237

EP - 1240

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 9

ER -

p16 and ARF: Activation of teenage proteins in old age

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this