p16 and ARF: Activation of teenage proteins in old age

Ande Satyanarayana; Karl Lenhard Rudolph

doi:10.1172/JCI23437

p16 and ARF: Activation of teenage proteins in old age

Ande Satyanarayana, Karl Lenhard Rudolph

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus - p16^INK4a and ARF - arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging (see the related article beginning on page 1299).

Original language	English (US)
Pages (from-to)	1237-1240
Number of pages	4
Journal	Journal of Clinical Investigation
Volume	114
Issue number	9
DOIs	https://doi.org/10.1172/JCI23437
State	Published - Nov 2004
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1172/JCI23437

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title = "p16 and ARF: Activation of teenage proteins in old age",

abstract = "Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus - p16INK4a and ARF - arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging (see the related article beginning on page 1299).",

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AU - Rudolph, Karl Lenhard

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N2 - Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus - p16INK4a and ARF - arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging (see the related article beginning on page 1299).

AB - Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus - p16INK4a and ARF - arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging (see the related article beginning on page 1299).

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p16 and ARF: Activation of teenage proteins in old age

Abstract

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