Abstract
Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode. Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation. Conclusion: Tumor hypoxia exists within pancreatic cancers. Copyright (C) 2000 Elsevier Science Inc.
Original language | English (US) |
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Pages (from-to) | 919-922 |
Number of pages | 4 |
Journal | International Journal of Radiation Oncology Biology Physics |
Volume | 48 |
Issue number | 4 |
DOIs | |
State | Published - Nov 1 2000 |
Externally published | Yes |
Keywords
- Adenocarcinoma
- Hypoxia
- Oxygenation
- Pancreas
ASJC Scopus subject areas
- Radiation
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research