TY - JOUR
T1 - Pediatric Cutaneous Mastocytosis
T2 - A Case Report and Literature Review
AU - Hale, Elizabeth
AU - Tidwell, Taylor
AU - Smith, Hallie
AU - Ramsey, Zach
AU - Powell, Matt
AU - Yu, Jack
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023/6
Y1 - 2023/6
N2 - An important component of innate immunity, mast cells contain intensely basophilic granules of anticoagulants (such as heparin) and vasoactive amines (histamine and others), playing key roles in the initiation of inflammation. They have a vast array of cell surface receptors for IgE and complements. FcεRI, with high affinity for IgE Fc terminals, respond to a wide variety of stimuli including damage-associated molecular pattern (DAMP) and pathogen-associated molecular pattern (PAMP). CD 88 and C3aR bind anaphylatoxins from the complement system. We report a case of infantile cutaneous mastocytosis with an extensive review of literature on both mastocytosis and mast cell function and dysfunction for pediatric plastic surgeons.
AB - An important component of innate immunity, mast cells contain intensely basophilic granules of anticoagulants (such as heparin) and vasoactive amines (histamine and others), playing key roles in the initiation of inflammation. They have a vast array of cell surface receptors for IgE and complements. FcεRI, with high affinity for IgE Fc terminals, respond to a wide variety of stimuli including damage-associated molecular pattern (DAMP) and pathogen-associated molecular pattern (PAMP). CD 88 and C3aR bind anaphylatoxins from the complement system. We report a case of infantile cutaneous mastocytosis with an extensive review of literature on both mastocytosis and mast cell function and dysfunction for pediatric plastic surgeons.
KW - cutaneous mastocytosis
KW - multiple maculopapules
UR - http://www.scopus.com/inward/record.url?scp=85164544191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85164544191&partnerID=8YFLogxK
U2 - 10.1177/27325016231162632
DO - 10.1177/27325016231162632
M3 - Article
AN - SCOPUS:85164544191
SN - 2732-5016
VL - 4
SP - 251
EP - 256
JO - Face
JF - Face
IS - 2
ER -