TY - JOUR
T1 - Performance of RAPID noncontrast CT stroke platform in large vessel occlusion and intracranial hemorrhage detection
AU - Yedavalli, Vivek
AU - Heit, Jeremy Josef
AU - Dehkharghani, Seena
AU - Haerian, Hafez
AU - Mcmenamy, John
AU - Honce, Justin
AU - Timpone, Vincent M.
AU - Harnain, Christopher
AU - Kesselman, Andrew
AU - Filly, Anthony
AU - Beardsley, Adam
AU - Sakamoto, Brian
AU - Song, Chris
AU - Montuori, James
AU - Navot, Benjamin
AU - Mena, Francisco Villar
AU - Giurgiutiu, Dan Victor
AU - Kitamura, Felipe
AU - Lima, Fabricio Oliveira
AU - Silva, Henrique
AU - Mont’Alverne, Francisco Jose
AU - Albers, Gregory
N1 - Publisher Copyright:
Copyright © 2023 Yedavalli, Heit, Dehkharghani, Haerian, Mcmenamy, Honce, Timpone, Harnain, Kesselman, Filly, Beardsley, Sakamoto, Song, Montuori, Navot, Mena, Giurgiutiu, Kitamura, Lima, Silva, Mont’Alverne and Albers.
PY - 2023
Y1 - 2023
N2 - Background: Noncontrast CT (NCCT) is used to evaluate for intracerebral hemorrhage (ICH) and ischemia in acute ischemic stroke (AIS). Large vessel occlusions (LVOs) are a major cause of AIS, but challenging to detect on NCCT. Aims: The purpose of this study is to evaluate an AI software called RAPID NCCT Stroke (RAPID, iSchemaView, Menlo Park, CA) for ICH and LVO detection compared to expert readers. Methods: In this IRB approved retrospective, multicenter study, stand-alone performance of the software was assessed based on the consensus of 3 neuroradiologists and sensitivity and specificity were determined. The platform’s performance was then compared to interpretation by readers comprised of eight general radiologists (GR) and three neuroradiologists (NR) in detecting ICH and hyperdense vessel sign (HVS) indicating LVO. Results: A total of 244 cases were included. Of the 244, 115 were LVOs and 26 were ICHs. One hundred three cases did not have LVO nor ICH. Stand-alone performance of the software demonstrated sensitivities and specificities of 96.2 and 99.5% for ICH and 63.5 and 95.1% for LVO detection. Compared to all 11 readers and eight GR readers only respectively, the software demonstrated superiority, achieving significantly higher sensitivities (63.5% versus 43.6%, p < 0.0001 and 63.5% versus 40.9%, p = 0.001). Conclusion: The RAPID NCCT Stroke platform demonstrates superior performance to radiologists for detecting LVO from a NCCT. Use of this software platform could lead to earlier LVO detection and expedited transfer of these patients to a thrombectomy capable center.
AB - Background: Noncontrast CT (NCCT) is used to evaluate for intracerebral hemorrhage (ICH) and ischemia in acute ischemic stroke (AIS). Large vessel occlusions (LVOs) are a major cause of AIS, but challenging to detect on NCCT. Aims: The purpose of this study is to evaluate an AI software called RAPID NCCT Stroke (RAPID, iSchemaView, Menlo Park, CA) for ICH and LVO detection compared to expert readers. Methods: In this IRB approved retrospective, multicenter study, stand-alone performance of the software was assessed based on the consensus of 3 neuroradiologists and sensitivity and specificity were determined. The platform’s performance was then compared to interpretation by readers comprised of eight general radiologists (GR) and three neuroradiologists (NR) in detecting ICH and hyperdense vessel sign (HVS) indicating LVO. Results: A total of 244 cases were included. Of the 244, 115 were LVOs and 26 were ICHs. One hundred three cases did not have LVO nor ICH. Stand-alone performance of the software demonstrated sensitivities and specificities of 96.2 and 99.5% for ICH and 63.5 and 95.1% for LVO detection. Compared to all 11 readers and eight GR readers only respectively, the software demonstrated superiority, achieving significantly higher sensitivities (63.5% versus 43.6%, p < 0.0001 and 63.5% versus 40.9%, p = 0.001). Conclusion: The RAPID NCCT Stroke platform demonstrates superior performance to radiologists for detecting LVO from a NCCT. Use of this software platform could lead to earlier LVO detection and expedited transfer of these patients to a thrombectomy capable center.
KW - acute
KW - ischemic stroke
KW - large vessel occlusion
KW - noncontrast CT
KW - stroke
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U2 - 10.3389/fneur.2023.1324088
DO - 10.3389/fneur.2023.1324088
M3 - Article
AN - SCOPUS:85180665843
SN - 1664-2295
VL - 14
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 1324088
ER -