TY - JOUR
T1 - Perifollicular linear projections
T2 - A dermatoscopic criterion for the diagnosis of lentigo maligna on the face
AU - Navarrete-Dechent, Cristian
AU - Jaimes, Natalia
AU - Dusza, Stephen W.
AU - Liopyris, Konstantinos
AU - Marchetti, Michael A.
AU - Cordova, Miguel
AU - Oliviero, Margaret
AU - Villaseca, Miguel A.
AU - Pulitzer, Melissa
AU - Busam, Klaus J.
AU - Rossi, Anthony M.
AU - Rabinovitz, Harold S.
AU - Nehal, Kishwer S.
AU - Scope, Alon
AU - Marghoob, Ashfaq A.
N1 - Publisher Copyright:
© 2023 American Academy of Dermatology, Inc.
PY - 2024/1
Y1 - 2024/1
N2 - Background: Lentigo maligna (LM) can mimic benign, flat, pigmented lesions and can be challenging to diagnose. Objective: To describe a new dermatoscopic feature termed “perifollicular linear projections (PLP)” as a diagnostic criterion for LM on the face. Methods: Retrospective study on reflectance confocal microscopy and dermatoscopy images of flat facial pigmented lesions originating from 2 databases. PLP were defined as short, linear, pigmented projections emanating from hair follicles. Dermatoscopy readers were blinded to the final histopathologic diagnosis. Results: From 83 consecutive LMs, 21/83 (25.3%) displayed “bulging of hair follicles” on reflectance confocal microscopy and 18 of these 21 (85.7%), displayed PLP on dermatoscopy. From a database of 2873 consecutively imaged and biopsied lesions, 252 flat-pigmented facial lesions were included. PLP was seen in 47/76 melanomas (61.8%), compared with 7/176 lesions (3.9%) with other diagnosis (P < .001). The sensitivity was 61.8% (95% CI, 49.9%-72.7%), specificity 96.0% (95% CI, 92.9%-98.4%). PLP was independently associated with LM diagnosis on multivariate analysis (OR 26.1 [95% CI, 9.6%-71.0]). Limitations: Retrospective study. Conclusion: PLP is a newly described dermatoscopic criterion that may add specificity and sensitivity to the early diagnosis of LM located on the face. We postulate that PLP constitutes an intermediary step in the LM progression model.
AB - Background: Lentigo maligna (LM) can mimic benign, flat, pigmented lesions and can be challenging to diagnose. Objective: To describe a new dermatoscopic feature termed “perifollicular linear projections (PLP)” as a diagnostic criterion for LM on the face. Methods: Retrospective study on reflectance confocal microscopy and dermatoscopy images of flat facial pigmented lesions originating from 2 databases. PLP were defined as short, linear, pigmented projections emanating from hair follicles. Dermatoscopy readers were blinded to the final histopathologic diagnosis. Results: From 83 consecutive LMs, 21/83 (25.3%) displayed “bulging of hair follicles” on reflectance confocal microscopy and 18 of these 21 (85.7%), displayed PLP on dermatoscopy. From a database of 2873 consecutively imaged and biopsied lesions, 252 flat-pigmented facial lesions were included. PLP was seen in 47/76 melanomas (61.8%), compared with 7/176 lesions (3.9%) with other diagnosis (P < .001). The sensitivity was 61.8% (95% CI, 49.9%-72.7%), specificity 96.0% (95% CI, 92.9%-98.4%). PLP was independently associated with LM diagnosis on multivariate analysis (OR 26.1 [95% CI, 9.6%-71.0]). Limitations: Retrospective study. Conclusion: PLP is a newly described dermatoscopic criterion that may add specificity and sensitivity to the early diagnosis of LM located on the face. We postulate that PLP constitutes an intermediary step in the LM progression model.
KW - biopsy
KW - dermatoscopy
KW - face
KW - lentigo maligna
KW - melanoma
KW - reflectance confocal microscopy
UR - http://www.scopus.com/inward/record.url?scp=85174463834&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85174463834&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2023.07.1036
DO - 10.1016/j.jaad.2023.07.1036
M3 - Article
C2 - 37634737
AN - SCOPUS:85174463834
SN - 0190-9622
VL - 90
SP - 52
EP - 57
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 1
ER -