TY - CHAP
T1 - Personalized chemotherapy of tumor disease based on system modeling
AU - Li, Biaoru
N1 - Funding Information:
Under the support of Dr. H. D. Preisler, we have set up the method to analyze clinical genomic analysis including single-cell genomic profiles of CD3, CD4 and CD8 from TIL and tumor cell from solid tumors and leukemia. The work is supported by National Cancer Institute IRG-91-022-09, USA for Dr. Biaoru Li. Nancy Debry and Shen Li contribute the chapter modification. Mention of trade names or commercial products in this article is solely for the purpose of providing specific information and does not imply recommendation.
Publisher Copyright:
© 2016 Bentham Science Publishers. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Clinically, personalized medicine also referred to as precision medicine is a new medical model to be directly tailored for the care of individual patients. It is often called "the right treatment for the right person at the right time." Most successful examples of personalized treatments require a rational clinical genomic analysis. Following Research and Development (R&D) of techniques and analysis of clinical genomic expression, genomic expression profile along with system modeling has been increasingly applied for personalized therapy. Now personalized chemotherapy, one of personalized therapy, has been brought forward to the field of cancer. According to protocol of personalized chemotherapy from tumor tissue sampling to clinical application in queue, I will introduce the entire process including clinical sampling, analyzing mRNA genomic expression level with its diagnosis, discovering gene expression signature by system modeling and uncovering sensitive drugs from drugbank for clinical application. At present, after next-generation sequencing is brought into the new field, system modeling related with drugs discovery will make great contribution for future personalized chemotherapy of tumor diseases.
AB - Clinically, personalized medicine also referred to as precision medicine is a new medical model to be directly tailored for the care of individual patients. It is often called "the right treatment for the right person at the right time." Most successful examples of personalized treatments require a rational clinical genomic analysis. Following Research and Development (R&D) of techniques and analysis of clinical genomic expression, genomic expression profile along with system modeling has been increasingly applied for personalized therapy. Now personalized chemotherapy, one of personalized therapy, has been brought forward to the field of cancer. According to protocol of personalized chemotherapy from tumor tissue sampling to clinical application in queue, I will introduce the entire process including clinical sampling, analyzing mRNA genomic expression level with its diagnosis, discovering gene expression signature by system modeling and uncovering sensitive drugs from drugbank for clinical application. At present, after next-generation sequencing is brought into the new field, system modeling related with drugs discovery will make great contribution for future personalized chemotherapy of tumor diseases.
KW - Cancer stem cells (CSCs)
KW - Circulating tumor cells (CTCs)
KW - Clinical genomic diagnosis
KW - Clinical genomics analysis
KW - Drug targeting
KW - Encyclopedia of DNA elements (ENCODE)
KW - Flow-cytometric cell sorting (FACS)
KW - Gene expression signature (GES)
KW - Genome-wide association studies (GWAS)
KW - Laser-captured micro-dissection (LCM)
KW - Magnetic cell separation (MACS)
KW - Networks
KW - Personalized chemotherapy
KW - Personalized medicine
KW - Proteomics
KW - Single nucleotide polymorphisms (SNP)
KW - System biology and system modeling
KW - Transcriptome
UR - http://www.scopus.com/inward/record.url?scp=85054057641&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054057641&partnerID=8YFLogxK
U2 - 10.2174/9781681081656116070008
DO - 10.2174/9781681081656116070008
M3 - Chapter
AN - SCOPUS:85054057641
T3 - Frontiers in Drug Design and Discovery
SP - 223
EP - 247
BT - Frontiers in Drug Design and Discovery
PB - Bentham Science Publishers B.V.
ER -
