Photobiomodulation therapy for repeated closed head injury in rats

Baocheng Yang; Juanyong Xu; Yong Li; Yan Dong; Yuyu Li; Lorelei Tucker; Luodan Yang; Xuemei Zong; Chongyun Wu; Tie Xu; Shuqun Hu; Quanguang Zhang; Xianliang Yan

doi:10.1002/jbio.201960117

Photobiomodulation therapy for repeated closed head injury in rats

Baocheng Yang, Juanyong Xu, Yong Li, Yan Dong, Yuyu Li, Lorelei Tucker, Luodan Yang, Xuemei Zong, Chongyun Wu, Tie Xu, Shuqun Hu, Quanguang Zhang, Xianliang Yan

Neuroscience and Regenerative Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Repeated traumatic brain injury, leads to cumulative neuronal injury and neurological impairments. There are currently no effective treatments to prevent these consequences. Growing interest is building in the use of transcranial photobiomodulation (PBM) therapy to treat traumatic brain injury. Here, we examined PBM in a repeated closed head injury (rCHI) rat model. Rats were administered a total of three closed head injuries, with each injury separated by 5 days. PBM treatment was initiated 2 hours after the first injury and administered daily for a total of 15 days. We found that PBM-treated rCHI rats had a significant reduction in motor ability, anxiety and cognitive deficits compared to CHI group. PBM group showed an increase of synaptic proteins and surviving neurons, along with a reduction in reactive gliosis and neuronal injury. These findings highlight the complexity of gliosis and neuronal injury following rCHI and suggest that PBM may be a viable treatment option to mitigate these effects and their detrimental consequences.

Original language	English (US)
Article number	e201960117
Journal	Journal of Biophotonics
Volume	13
Issue number	2
DOIs	https://doi.org/10.1002/jbio.201960117
State	Published - Feb 1 2020

Keywords

gliosis
neuronal death
photobiomodulation
repeated closed head injury

ASJC Scopus subject areas

General Chemistry
General Materials Science
General Biochemistry, Genetics and Molecular Biology
General Engineering
General Physics and Astronomy

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10.1002/jbio.201960117

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title = "Photobiomodulation therapy for repeated closed head injury in rats",

abstract = "Repeated traumatic brain injury, leads to cumulative neuronal injury and neurological impairments. There are currently no effective treatments to prevent these consequences. Growing interest is building in the use of transcranial photobiomodulation (PBM) therapy to treat traumatic brain injury. Here, we examined PBM in a repeated closed head injury (rCHI) rat model. Rats were administered a total of three closed head injuries, with each injury separated by 5 days. PBM treatment was initiated 2 hours after the first injury and administered daily for a total of 15 days. We found that PBM-treated rCHI rats had a significant reduction in motor ability, anxiety and cognitive deficits compared to CHI group. PBM group showed an increase of synaptic proteins and surviving neurons, along with a reduction in reactive gliosis and neuronal injury. These findings highlight the complexity of gliosis and neuronal injury following rCHI and suggest that PBM may be a viable treatment option to mitigate these effects and their detrimental consequences.",

keywords = "gliosis, neuronal death, photobiomodulation, repeated closed head injury",

author = "Baocheng Yang and Juanyong Xu and Yong Li and Yan Dong and Yuyu Li and Lorelei Tucker and Luodan Yang and Xuemei Zong and Chongyun Wu and Tie Xu and Shuqun Hu and Quanguang Zhang and Xianliang Yan",

note = "Funding Information: This study was supported by an American Heart Association Innovative Project Award (18IPA34170148), Jiangsu Social Development and Natural Science Foundation (BE2016645, BK20161153, BE2017641), and Xuzhou National Clinical Key Specialty Cultivation Project (2018ZK004) and Qing Lan Project. Funding Information: This study was supported by an American Heart Association Innovative Project Award (18IPA34170148), Jiangsu Social Development and Natural Science Foundation (BE2016645, BK20161153, BE2017641), and Xuzhou National Clinical Key Specialty Cultivation Project (2018ZK004) and Qing Lan Project. Publisher Copyright: {\textcopyright} 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

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AU - Yang, Baocheng

AU - Xu, Juanyong

AU - Li, Yong

AU - Dong, Yan

AU - Li, Yuyu

AU - Tucker, Lorelei

AU - Yang, Luodan

AU - Zong, Xuemei

AU - Wu, Chongyun

AU - Xu, Tie

AU - Hu, Shuqun

AU - Zhang, Quanguang

AU - Yan, Xianliang

N1 - Funding Information: This study was supported by an American Heart Association Innovative Project Award (18IPA34170148), Jiangsu Social Development and Natural Science Foundation (BE2016645, BK20161153, BE2017641), and Xuzhou National Clinical Key Specialty Cultivation Project (2018ZK004) and Qing Lan Project. Funding Information: This study was supported by an American Heart Association Innovative Project Award (18IPA34170148), Jiangsu Social Development and Natural Science Foundation (BE2016645, BK20161153, BE2017641), and Xuzhou National Clinical Key Specialty Cultivation Project (2018ZK004) and Qing Lan Project. Publisher Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Repeated traumatic brain injury, leads to cumulative neuronal injury and neurological impairments. There are currently no effective treatments to prevent these consequences. Growing interest is building in the use of transcranial photobiomodulation (PBM) therapy to treat traumatic brain injury. Here, we examined PBM in a repeated closed head injury (rCHI) rat model. Rats were administered a total of three closed head injuries, with each injury separated by 5 days. PBM treatment was initiated 2 hours after the first injury and administered daily for a total of 15 days. We found that PBM-treated rCHI rats had a significant reduction in motor ability, anxiety and cognitive deficits compared to CHI group. PBM group showed an increase of synaptic proteins and surviving neurons, along with a reduction in reactive gliosis and neuronal injury. These findings highlight the complexity of gliosis and neuronal injury following rCHI and suggest that PBM may be a viable treatment option to mitigate these effects and their detrimental consequences.

AB - Repeated traumatic brain injury, leads to cumulative neuronal injury and neurological impairments. There are currently no effective treatments to prevent these consequences. Growing interest is building in the use of transcranial photobiomodulation (PBM) therapy to treat traumatic brain injury. Here, we examined PBM in a repeated closed head injury (rCHI) rat model. Rats were administered a total of three closed head injuries, with each injury separated by 5 days. PBM treatment was initiated 2 hours after the first injury and administered daily for a total of 15 days. We found that PBM-treated rCHI rats had a significant reduction in motor ability, anxiety and cognitive deficits compared to CHI group. PBM group showed an increase of synaptic proteins and surviving neurons, along with a reduction in reactive gliosis and neuronal injury. These findings highlight the complexity of gliosis and neuronal injury following rCHI and suggest that PBM may be a viable treatment option to mitigate these effects and their detrimental consequences.

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KW - photobiomodulation

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Photobiomodulation therapy for repeated closed head injury in rats

Abstract

Keywords

ASJC Scopus subject areas

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