Physical Models and Simpler Dosimetric Descriptors of Radiation Late Toxicity

Feng Ming (Spring) Kong, Charlie Pan, Avraham Eisbruch, Randall K.Ten Haken

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Predicting radiation damage to specific organs is becoming ever more challenging with the use of intensity-modulated beams, nonuniform dose distributions, partial organ irradiation, and interpatient and even intraorgan variations in radiation sensitivity. Data-based physical models can be of use in summarizing complicated dose-volume data to help describe clinical outcomes and ultimately aid in the prediction of clinical toxicity. This article attempts to provide a brief overview of the use of normal tissue complication probability (NTCP) models and other simple dose/volume metrics to describe a few clinically significant complications (either frequent or serious) associated with radiation therapy of the head and neck, thorax, and abdominal-pelvic regions. Specifically, it reviews the application of these methods for late toxicities of the parotid, lung, heart, spinal cord, liver, and rectum. It focuses on organ-specific NTCP parameters as well as simple dosimetric descriptors that might be used to help treatment plan evaluation in clinical practice.

Original languageEnglish (US)
Pages (from-to)108-120
Number of pages13
JournalSeminars in Radiation Oncology
Issue number2
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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