Plasma renin activity is associated with bone mineral density in premenopausal women

F. A. Tylavsky, K. C. Johnson, J. Y. Wan, G. Harshfield

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Bone mineral density (BMD), plasma renin activity (PRA) and dietary calcium and sodium were evaluated in 47 Caucasian premenopausal women. All subjects were free of any disorder or medications known to affect calcium or bone metabolism. Those subjects with low PRA (< 1.3 ng/ml) had 4.3% lower BMD at the distal radius (p = 0.03). Other skeletal sites appeared to have lower BMD in subjects with low PRA but these differences were not statistically significant. There was a tendency for the low PRA group to have a lower dietary intake of calcium (p = 0.06) as compared with the normal PRA group (≤ 1.3 and < 4.0 ng/ml). Positive correlations were found between calcium intake and PRA (r = 0.26, p = 0.09); and between calcium/sodium intake and distal radial BMD (r = 0.31, p = 0.04), mid-radial BMD (r = 0.30, p = 0.04), total hip BMD (r = 0.23, p = 0.12) and total body BMD (r = 0.27, p = 0.07). This study provides preliminary evidence that a sodium intake > 3400 mg/day, as evidenced by the suppression of PRA, may affect bone mass and the effect may be modified by the level of calcium intake. Additional research is needed to replicate our findings with a larger sample size.

Original languageEnglish (US)
Pages (from-to)136-140
Number of pages5
JournalOsteoporosis International
Issue number2
StatePublished - 1998


  • Bone density
  • Dietary calcium
  • Dietary sodium
  • Females
  • Renin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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