Platelet chemokines in vascular disease

Christian A. Gleissner, Philipp Von Hundelshausen, Klaus Ley

Research output: Contribution to journalReview articlepeer-review

228 Scopus citations


Platelets are a rich source of different chemokines and express chemokine receptors. CXCL4 is highly abundant in platelets and involved in promoting monocyte arrest from rolling and monocyte differentiation to macrophages. CXCL4 can also associate with CCL5 and amplify its effect on monocytes. The megakaryocyte CXCL7 gene product is proteolytically cleaved into the strong neutrophil chemoattractant, NAP-2, which has also been implicated in repair cell homing to vascular lesions. Platelet adhesion can induce release of CCL2 and CXCL8 from endothelial cells. Conversely, the chemokines CCLl7, CCL22, and CXCL12 made by other cells amplify platelet activation. Platelet chemokines enhance recruitment of various hematopoietic cells to the vascular wall, fostering processes such as neointima formation, atherosclerosis, and thrombosis, but also vessel repair and regeneration after vascular injury.

Original languageEnglish (US)
Pages (from-to)1920-1927
Number of pages8
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number11
StatePublished - Nov 2008
Externally publishedYes


  • Angiogenesis
  • Atherosclerosis
  • Chemokines
  • Platelets
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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