@article{3367da7679ed41a292138a03ba772a0c,
title = "Poor prognosis acute myelogenous leukemia 2 - Biological and molecular biological characteristics and treatment outcome",
abstract = "Biological and molecular biological studies were performed on the marrow cells of 25 patients with poor prognosis AML to both characterize this type of leukemia and to assess the relationship between the parameters which were measured and treatment outcome. Treatment failure associated with high levels of telomerase activity and low levels of IL6 transcripts. Studies of the effects of amifostine on these parameters demonstrated that this agent reduced telomerase activity in aspirates of AML marrows. These data suggest that the beneficial effect associated with the administration of amifostine after the end of chemotherapy is likely, to be due to a reduction in the rate at which the surviving leukemia cells repopulate the marrow. Copyright (C) 2000 Elsevier Science Ltd.",
keywords = "AML, Amifostine, Cytokines, Remission induction",
author = "Biaoru Li and Jie Yang and Ming Tao and Jaya Nayini and Erzsebet Horvath and Harpareet Chopra and Peterm Meyer and Paramesaran Venugopal and Preisler, {Harvey D.}",
note = "Funding Information: This work is supported by, the National Institute of Health/National Cancer Institute PO-1 CA75606-3 and by a contribution from the AIza Corporation. B. Li provided analysis and data interpretation, drafted the article and gave critical revision. J. Yang and J. Navini assisted with data interpretation. E. Horvath collected the data and provided technical support. H. Chopra provided data interpretation. P.M. Meyer provided statistically expertise. P. Venugopal provided study material, gave critical support to the review and gave final approval. H.D. Preisler provided the concept, design, assisted with data interpretation and drafting the article, obtained funding, gave administrative support and gave final approval. ",
year = "2000",
month = sep,
day = "1",
doi = "10.1016/S0145-2126(00)00035-7",
language = "English (US)",
volume = "24",
pages = "777--789",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "9",
}
