TY - JOUR
T1 - Population-based geospatial and molecular epidemiologic study of tuberculosis transmission dynamics, Botswana, 2012–2016
AU - Zetola, Nicola M.
AU - Moonan, Patrick K.
AU - Click, Eleanor
AU - Oeltmann, John E.
AU - Basotli, Joyce
AU - Wen, Xiao Jun
AU - Boyd, Rosanna
AU - Tobias, James L.
AU - Finlay, Alyssa
AU - Modongo, Chawangwa
N1 - Publisher Copyright:
© 2021 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2021/3
Y1 - 2021/3
N2 - Tuberculosis (TB) elimination requires interrupting transmission of Mycobacterium tuberculosis. We used a multidisciplinary approach to describe TB transmission in 2 sociodemographically distinct districts in Botswana (Kopanyo Study). During August 2012–March 2016, all patients who had TB were enrolled, their sputum samples were cultured, and M. tuberculosis isolates were genotyped by using 24-locus mycobacterial interspersed repetitive units–variable number of tandem repeats. Of 5,515 TB patients, 4,331 (79%) were enrolled. Annualized TB incidence varied by geography (range 66–1,140 TB patients/100,000 persons). A total of 1,796 patient isolates had valid genotyping results and residential geocoordinates; 780 (41%) patients were involved in a localized TB transmission event. Residence in areas with a high burden of TB, age <24 years, being a current smoker, and unemployment were factors associated with localized transmission events. Patients with known HIV-positive status had lower odds of being involved in localized transmission.
AB - Tuberculosis (TB) elimination requires interrupting transmission of Mycobacterium tuberculosis. We used a multidisciplinary approach to describe TB transmission in 2 sociodemographically distinct districts in Botswana (Kopanyo Study). During August 2012–March 2016, all patients who had TB were enrolled, their sputum samples were cultured, and M. tuberculosis isolates were genotyped by using 24-locus mycobacterial interspersed repetitive units–variable number of tandem repeats. Of 5,515 TB patients, 4,331 (79%) were enrolled. Annualized TB incidence varied by geography (range 66–1,140 TB patients/100,000 persons). A total of 1,796 patient isolates had valid genotyping results and residential geocoordinates; 780 (41%) patients were involved in a localized TB transmission event. Residence in areas with a high burden of TB, age <24 years, being a current smoker, and unemployment were factors associated with localized transmission events. Patients with known HIV-positive status had lower odds of being involved in localized transmission.
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U2 - 10.3201/eid2703.203840
DO - 10.3201/eid2703.203840
M3 - Article
C2 - 33622470
AN - SCOPUS:85101513832
SN - 1080-6040
VL - 27
SP - 835
EP - 844
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 3
ER -
