Abstract
We report a case of a 72-year-old man presenting with a 2-month history of a persistent, painful rash of the chest, axilla, and back. He had a history of recently resolved varicella zoster virus reactivation in the same distribution of the current rash and metastatic malignant melanoma treated with nivolumab and ipilimumab. The histopathology was consistent with granulomatous dermatitis (GD), and a diagnosis of postherpetic isotopic response manifesting as GD was made. Given the paucity of reported cases of postherpetic GD in the setting of treatment with immune checkpoint inhibitors (ICIs), we discuss the clinicopathologic features of this case and potential mechanisms by which ICIs may contribute to the development of granulomatous disease.
Original language | English (US) |
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Pages (from-to) | 30-33 |
Number of pages | 4 |
Journal | Journal of Cutaneous Pathology |
Volume | 51 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2024 |
Keywords
- Wolf's isotopic response
- dermatitis
- granulomatous
- immune checkpoint inhibitor
- postherpetic
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Dermatology