Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome

Mark O. Goodarzi; Heath J. Antoine; Marita Pall; Jinrui Cui; Xiuqing Guo; Ricardo Azziz

doi:10.1016/j.fertnstert.2006.11.041

Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome

Mark O. Goodarzi, Heath J. Antoine, Marita Pall, Jinrui Cui, Xiuqing Guo, Ricardo Azziz

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3β (GSK3B) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3β contributes to the pathophysiology and inherited basis of PCOS.

Original language	English (US)
Pages (from-to)	1473-1476
Number of pages	4
Journal	Fertility and sterility
Volume	87
Issue number	6
DOIs	https://doi.org/10.1016/j.fertnstert.2006.11.041
State	Published - Jun 2007
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.fertnstert.2006.11.041

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title = "Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome",

abstract = "In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3β (GSK3B) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3β contributes to the pathophysiology and inherited basis of PCOS.",

author = "Goodarzi, {Mark O.} and Antoine, {Heath J.} and Marita Pall and Jinrui Cui and Xiuqing Guo and Ricardo Azziz",

note = "Funding Information: Supported in part by National Institutes of Health (Bethesda, Maryland) grants R03-HD42077, R01-HD29364, K24-HD01346-01, and M01-RR00425 and by the Helping Hand of Los Angeles (Los Angeles, California). ",

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T1 - Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome

AU - Goodarzi, Mark O.

AU - Antoine, Heath J.

AU - Pall, Marita

AU - Cui, Jinrui

AU - Guo, Xiuqing

AU - Azziz, Ricardo

N1 - Funding Information: Supported in part by National Institutes of Health (Bethesda, Maryland) grants R03-HD42077, R01-HD29364, K24-HD01346-01, and M01-RR00425 and by the Helping Hand of Los Angeles (Los Angeles, California).

PY - 2007/6

Y1 - 2007/6

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AB - In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3β (GSK3B) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3β contributes to the pathophysiology and inherited basis of PCOS.

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Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome

Abstract

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