@article{4bdd4afc837047f58668a5254c7de8a4,
title = "Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder",
abstract = "In this paper, we report the rate of previously undiagnosed obstructive sleep apnea (OSA) in a randomized clinical trial (RCT) of suicidal patients with major depressive disorder (MDD). One hundred and twenty-five suicidal adults with MDD were recruited into a RCT. None were suspected to have OSA. Fourteen percent met diagnostic criteria for OSA. The Apnea Hypopnea Index (AHI) was predicted by increasing age, male sex, and higher Body Mass Index. However, neither the degree of daytime sleepiness nor the degree of insomnia predicted AHI severity. A high degree of suspicion is warranted for OSA in suicidal patients with MDD, and for patients with treatment-resistant depression. ClinicalTrials.gov",
keywords = "Major depressive disorder, Obstructive sleep apnea, Suicide, Treatment-resistance",
author = "McCall, {William V.} and Benca, {Ruth M.} and Rumble, {Meredith E.} and Doug Case and Rosenquist, {Peter B.} and Krystal, {Andrew D.}",
note = "Funding Information: Dr. McCall receives honoraria from Wolters Kluwer Publishing, CME Outfitters, and Anthem Inc., and research support from Merck and MECTA Corp, and is a scientific advisor for Sage Therapeutics. Dr Benca is a consultant for Eisai, Jazz and Merck & Co., and receives grant support from Merck. Dr Rumble receives research support from Merck & Co. Dr Krystal receives grant support from NIH, Janssen, Jazz, Axsome and Reveal Biomarkers, and is a consultant to Adare, Eisai, Ferring, Galderma, Idorsia, Jazz, Janssen, Takeda, Merck, Neurocrine, Pernix, Physician's Seal. The other authors note no disclosures. Funding Information: Dr. McCall receives honoraria from Wolters Kluwer Publishing, CME Outfitters, and Anthem Inc., and research support from Merck and MECTA Corp , and is a scientific advisor for Sage Therapeutics. Dr Benca is a consultant for Eisai, Jazz and Merck & Co., and receives grant support from Merck. Dr Rumble receives research support from Merck & Co. Dr Krystal receives grant support from NIH , Janssen , Jazz , Axsome and Reveal Biomarkers , and is a consultant to Adare, Eisai , Ferring , Galderma , Idorsia , Jazz , Janssen , Takeda , Merck , Neurocrine , Pernix , Physician's Seal. The other authors note no disclosures. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = sep,
doi = "10.1016/j.jpsychires.2019.06.015",
language = "English (US)",
volume = "116",
pages = "147--150",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
}
