Primary evaluation and management of statin therapy complications

Dean A. Seehusen, Chad A. Asplund, Dawn R. Johnson, Kevin A. Horde

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


HMG-CoA reductase inhibitors (statins) have become one of the most commonly prescribed classes of medications in the United States. While serious adverse events are rare, less serious events are frequently seen. Published guidelines recommend initial screening labs as well as ongoing monitoring of liver enzymes during therapy. Up to 5% of patients will have some muscle complaints while taking statins. Therefore, primary care clinicians will often be faced with real or potential complications of statin therapy. There are well established risk factors for development of these complications. Being aware of a patient's risk and using the lowest effective dose minimizes the occurrence of adverse events. The great majority of these abnormalities either do not require discontinuation of therapy or require only brief interruption of therapy. Judicious and systematic use of laboratory testing will minimize needless evaluation and premature discontinuation of statin therapy.

Original languageEnglish (US)
Pages (from-to)250-256
Number of pages7
JournalSouthern medical journal
Issue number3
StatePublished - Mar 1 2006


  • Adverse effects
  • Cholesterol
  • Hydroxymethylglutaryl-CoA reductase inhibitors
  • Liver function tests
  • Myopathy

ASJC Scopus subject areas

  • Medicine(all)


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