Production of interleukin-1-receptor antagonist during experimental endotoxaemia

E. V. Granowitz; D. D. Poutsiaka; J. G. Cannon; S. M. Wolff; C. A. Dinarello; A. A. Santos; D. W. Wilmore

doi:10.1016/0140-6736(91)92725-H

Production of interleukin-1-receptor antagonist during experimental endotoxaemia

E. V. Granowitz, D. D. Poutsiaka, J. G. Cannon, S. M. Wolff, C. A. Dinarello, A. A. Santos, D. W. Wilmore

Medical Laboratory, Imaging and Radiologic Sciences

Research output: Contribution to journal › Article › peer-review

279 Scopus citations

Abstract

Interleukin-1 (IL-1) has been implicated in the pathogenesis of sepsis. IL-1-receptor antagonist (IL-1ra) is a naturally occurring inhibitor of IL-1 activity that competes with IL-1 for occupancy of cell-surface receptors but possesses no agonist activity. We induced endotoxaemia in 9 healthy human volunteers by injection of Escherichia coliendotoxin, and measured plasma concentrations of IL-1 and IL-1ra by radioimmunoassay during the next 24 h. Peak plasma concentrations of IL-1ra were about a hundred-fold greater than those of IL-1β. No IL-1 or IL-1ra were detectable in the plasma of 4 volunteers injected with saline. Our results suggest that the predominant natural response to endotoxin in man is the production of antagonist rather than agonist.

Original language	English (US)
Pages (from-to)	1423-1424
Number of pages	2
Journal	The Lancet
Volume	338
Issue number	8780
DOIs	https://doi.org/10.1016/0140-6736(91)92725-H
State	Published - Dec 7 1991

ASJC Scopus subject areas

Medicine(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0140-6736(91)92725-H

Cite this

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title = "Production of interleukin-1-receptor antagonist during experimental endotoxaemia",

abstract = "Interleukin-1 (IL-1) has been implicated in the pathogenesis of sepsis. IL-1-receptor antagonist (IL-1ra) is a naturally occurring inhibitor of IL-1 activity that competes with IL-1 for occupancy of cell-surface receptors but possesses no agonist activity. We induced endotoxaemia in 9 healthy human volunteers by injection of Escherichia coliendotoxin, and measured plasma concentrations of IL-1 and IL-1ra by radioimmunoassay during the next 24 h. Peak plasma concentrations of IL-1ra were about a hundred-fold greater than those of IL-1β. No IL-1 or IL-1ra were detectable in the plasma of 4 volunteers injected with saline. Our results suggest that the predominant natural response to endotoxin in man is the production of antagonist rather than agonist.",

author = "Granowitz, {E. V.} and Poutsiaka, {D. D.} and Cannon, {J. G.} and Wolff, {S. M.} and Dinarello, {C. A.} and Santos, {A. A.} and Wilmore, {D. W.}",

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T1 - Production of interleukin-1-receptor antagonist during experimental endotoxaemia

AU - Granowitz, E. V.

AU - Poutsiaka, D. D.

AU - Cannon, J. G.

AU - Wolff, S. M.

AU - Dinarello, C. A.

AU - Santos, A. A.

AU - Wilmore, D. W.

PY - 1991/12/7

Y1 - 1991/12/7

N2 - Interleukin-1 (IL-1) has been implicated in the pathogenesis of sepsis. IL-1-receptor antagonist (IL-1ra) is a naturally occurring inhibitor of IL-1 activity that competes with IL-1 for occupancy of cell-surface receptors but possesses no agonist activity. We induced endotoxaemia in 9 healthy human volunteers by injection of Escherichia coliendotoxin, and measured plasma concentrations of IL-1 and IL-1ra by radioimmunoassay during the next 24 h. Peak plasma concentrations of IL-1ra were about a hundred-fold greater than those of IL-1β. No IL-1 or IL-1ra were detectable in the plasma of 4 volunteers injected with saline. Our results suggest that the predominant natural response to endotoxin in man is the production of antagonist rather than agonist.

AB - Interleukin-1 (IL-1) has been implicated in the pathogenesis of sepsis. IL-1-receptor antagonist (IL-1ra) is a naturally occurring inhibitor of IL-1 activity that competes with IL-1 for occupancy of cell-surface receptors but possesses no agonist activity. We induced endotoxaemia in 9 healthy human volunteers by injection of Escherichia coliendotoxin, and measured plasma concentrations of IL-1 and IL-1ra by radioimmunoassay during the next 24 h. Peak plasma concentrations of IL-1ra were about a hundred-fold greater than those of IL-1β. No IL-1 or IL-1ra were detectable in the plasma of 4 volunteers injected with saline. Our results suggest that the predominant natural response to endotoxin in man is the production of antagonist rather than agonist.

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Production of interleukin-1-receptor antagonist during experimental endotoxaemia

Abstract

ASJC Scopus subject areas

UN SDGs

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