Provincial distribution of three HIV-1 resistant polymorphisms (CCR5- Δ 32, CCR2-64I, and SDF1-3′ A) in China

Junhua Xiao; Fang Hu; Hongyan Xu; Bing Su; Yueming Jiang; Jingchun Luo; Weiling Zhang; Jiazhen Tan; Li Jin; Daru Lu

Provincial distribution of three HIV-1 resistant polymorphisms (CCR5- Δ 32, CCR2-64I, and SDF1-3′ A) in China

Junhua Xiao, Fang Hu, Hongyan Xu, Bing Su, Yueming Jiang, Jingchun Luo, Weiling Zhang, Jiazhen Tan, Li Jin, Daru Lu

Research output: Contribution to journal › Article › peer-review

Abstract

CCR5- Δ 32, CCR2-64I, mutants in two chemokine receptors and SDF1-3′ A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Δ 32 was observed. CCR2-64I and SDF1-3′ A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.

Original language	English (US)
Pages (from-to)	16-20
Number of pages	5
Journal	Science in China, Series C: Life Sciences
Volume	43
Issue number	1
State	Published - Jan 1 2000
Externally published	Yes

Keywords

AIDS
HIV-1
PCR-RFLP

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Environmental Science
General Agricultural and Biological Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Provincial distribution of three HIV-1 resistant polymorphisms (CCR5- Δ 32, CCR2-64I, and SDF1-3′ A) in China",

abstract = "CCR5- Δ 32, CCR2-64I, mutants in two chemokine receptors and SDF1-3′ A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Δ 32 was observed. CCR2-64I and SDF1-3′ A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.",

keywords = "AIDS, HIV-1, PCR-RFLP",

author = "Junhua Xiao and Fang Hu and Hongyan Xu and Bing Su and Yueming Jiang and Jingchun Luo and Weiling Zhang and Jiazhen Tan and Li Jin and Daru Lu",

year = "2000",

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day = "1",

language = "English (US)",

volume = "43",

pages = "16--20",

journal = "Science in China, Series C: Life Sciences",

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TY - JOUR

T1 - Provincial distribution of three HIV-1 resistant polymorphisms (CCR5- Δ 32, CCR2-64I, and SDF1-3′ A) in China

AU - Xiao, Junhua

AU - Hu, Fang

AU - Xu, Hongyan

AU - Su, Bing

AU - Jiang, Yueming

AU - Luo, Jingchun

AU - Zhang, Weiling

AU - Tan, Jiazhen

AU - Jin, Li

AU - Lu, Daru

PY - 2000/1/1

Y1 - 2000/1/1

N2 - CCR5- Δ 32, CCR2-64I, mutants in two chemokine receptors and SDF1-3′ A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Δ 32 was observed. CCR2-64I and SDF1-3′ A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.

AB - CCR5- Δ 32, CCR2-64I, mutants in two chemokine receptors and SDF1-3′ A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Δ 32 was observed. CCR2-64I and SDF1-3′ A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.

KW - AIDS

KW - HIV-1

KW - PCR-RFLP

UR - http://www.scopus.com/inward/record.url?scp=23044499519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23044499519&partnerID=8YFLogxK

M3 - Article

C2 - 18763111

SN - 1006-9305

VL - 43

SP - 16

EP - 20

JO - Science in China, Series C: Life Sciences

JF - Science in China, Series C: Life Sciences

IS - 1

ER -

Provincial distribution of three HIV-1 resistant polymorphisms (CCR5- Δ 32, CCR2-64I, and SDF1-3′ A) in China

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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