TY - JOUR
T1 - Psychological and physical stress induce differential effects on human colonic motility
AU - Rao, Satish S.C.
AU - Hatfield, Renae A.
AU - Suls, Jerry M.
AU - Chamberlain, Mindi J.
N1 - Funding Information:
This study was supported by grants from the AGA-SKF Beecham Clinical Research Award and by Grant RROOO59 from the General Clinical Research Center’s Program, National Institutes of Health. We acknowledge the valuable critique of Dr. Robert Summers and the help of Mrs. Jennifer Leistikow in the preparation of this manuscript. Portions of this manuscript were presented to the 15th International Symposium on Gastrointestinal Motility, Rome, Nov. 5–9, 1995 and published as an abstract (Neurogastroenterol Mot 1995; 7:A282).
PY - 1998/6
Y1 - 1998/6
N2 - Objective: Stress modulates gut function, but whether the type of stressor influences colonic motor activity is unclear. The motor patterns and regional variations are also poorly understood. Our aim was to determine the effects of psychological and physical stress on colonic motility. Methods: Ambulatory colonic manometry was performed by placing a six-sensor probe up to the midtransverse colon, without sedation, in 12 healthy subjects. Five hours later, a dichotomous listening test (psychological stress) was performed, which was preceded by listening to a narrative passage (control); recovery entailed listening to relaxing music (1 h each). Subsequently, intermittent hand immersion in cold (4°C) water (physical stress) was performed, preceded by hand immersion in warm (37°C) water ( 1/2 -h each). Colonic pressure activity and cardiovascular responses were measured throughout the study. Results: When compared with the control period, both stressors induced a greater number of pressure waves (p < 0.05), and the area under the curve (p < 0.01), but only physical stress increased (p < 0.05) pulse rate and blood pressure. There were no regional differences in colonic motility. During recovery, the motor activity returned to baseline after physical stress, but remained high after psychological stress. Psychological stress induced more (p < 0.05) propagated contractions, whereas physical stress induced more (p < 0.05) simultaneous contractions. Conclusions: Both stressors enhanced colonic motor activity, but psychological stress induced a prolonged response with propagated activity and without appreciable autonomic response. Thus, colonic motor responses may vary depending on the stressor.
AB - Objective: Stress modulates gut function, but whether the type of stressor influences colonic motor activity is unclear. The motor patterns and regional variations are also poorly understood. Our aim was to determine the effects of psychological and physical stress on colonic motility. Methods: Ambulatory colonic manometry was performed by placing a six-sensor probe up to the midtransverse colon, without sedation, in 12 healthy subjects. Five hours later, a dichotomous listening test (psychological stress) was performed, which was preceded by listening to a narrative passage (control); recovery entailed listening to relaxing music (1 h each). Subsequently, intermittent hand immersion in cold (4°C) water (physical stress) was performed, preceded by hand immersion in warm (37°C) water ( 1/2 -h each). Colonic pressure activity and cardiovascular responses were measured throughout the study. Results: When compared with the control period, both stressors induced a greater number of pressure waves (p < 0.05), and the area under the curve (p < 0.01), but only physical stress increased (p < 0.05) pulse rate and blood pressure. There were no regional differences in colonic motility. During recovery, the motor activity returned to baseline after physical stress, but remained high after psychological stress. Psychological stress induced more (p < 0.05) propagated contractions, whereas physical stress induced more (p < 0.05) simultaneous contractions. Conclusions: Both stressors enhanced colonic motor activity, but psychological stress induced a prolonged response with propagated activity and without appreciable autonomic response. Thus, colonic motor responses may vary depending on the stressor.
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U2 - 10.1111/j.1572-0241.1998.00293.x
DO - 10.1111/j.1572-0241.1998.00293.x
M3 - Article
C2 - 9647034
AN - SCOPUS:0032105412
SN - 0002-9270
VL - 93
SP - 985
EP - 990
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 6
ER -