TY - JOUR
T1 - Racial differences in the age-related increase in left ventricular mass in youths
AU - Harshfield, Gregory A.
AU - Koelsch, David W.
AU - Pulliam, Derrick A.
AU - Alpert, Bruce S.
AU - Richey, Phyllis A.
AU - Becker, Judith A.
PY - 1994/12
Y1 - 1994/12
N2 - We determined the factors related to left ventricular mass adjusted for body size in 60 black (mean age, 13±2 years) and 40 white (mean age, 14±2 years) normotensive youths. The factors examined included age, sex, systolic blood pressure, diastolic blood pressure, plasma renin activity, plasma aldosterone concentration, and sodium and potassium intake as determined by 24-hour excretion. Sex (β=13.3, P<.003), age (β=2.88, P<.001), and systolic blood pressure (β=0.41, P<.02) were independent predictors in the sample as a whole, accounting for 37% of the variance of left ventricular mass adjusted for height. Separate analyses were performed for black and white subjects. In the black subjects, age (β=4.4, P<.004) followed by sex (β=11.85, P<.02) were independent factors, accounting for 43% of the variance of left ventricular mass adjusted for height. In contrast, in white subjects systolic blood pressure (β=0.4, P<.003) followed by sodium excretion (β=0.13, P<.05) were independent factors, with gender (β=8.89, P<.07) tending to account for 36% of the variance. Similar results were observed for left ventricular mass adjusted for body surface area. In conclusion, the age-related increase in adjusted left ventricular mass in black but not white youths may in part account for the early development of cardiovascular disease among the black population.
AB - We determined the factors related to left ventricular mass adjusted for body size in 60 black (mean age, 13±2 years) and 40 white (mean age, 14±2 years) normotensive youths. The factors examined included age, sex, systolic blood pressure, diastolic blood pressure, plasma renin activity, plasma aldosterone concentration, and sodium and potassium intake as determined by 24-hour excretion. Sex (β=13.3, P<.003), age (β=2.88, P<.001), and systolic blood pressure (β=0.41, P<.02) were independent predictors in the sample as a whole, accounting for 37% of the variance of left ventricular mass adjusted for height. Separate analyses were performed for black and white subjects. In the black subjects, age (β=4.4, P<.004) followed by sex (β=11.85, P<.02) were independent factors, accounting for 43% of the variance of left ventricular mass adjusted for height. In contrast, in white subjects systolic blood pressure (β=0.4, P<.003) followed by sodium excretion (β=0.13, P<.05) were independent factors, with gender (β=8.89, P<.07) tending to account for 36% of the variance. Similar results were observed for left ventricular mass adjusted for body surface area. In conclusion, the age-related increase in adjusted left ventricular mass in black but not white youths may in part account for the early development of cardiovascular disease among the black population.
KW - blood pressure
KW - left ventricular mass
KW - racial differences
KW - sex differences
KW - sodium excretion
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U2 - 10.1161/01.HYP.24.6.747
DO - 10.1161/01.HYP.24.6.747
M3 - Article
C2 - 7995632
AN - SCOPUS:0028004331
SN - 0194-911X
VL - 24
SP - 747
EP - 751
JO - Hypertension
JF - Hypertension
IS - 6
ER -