Regenerative therapy for cardiomyopathies

Zi Wang; Xuan Su; Muhammad Ashraf; Il Man Kim; Neal L. Weintraub; Meng Jiang; Yaoliang Tang

doi:10.1007/s12265-018-9807-z

Regenerative therapy for cardiomyopathies

Zi Wang, Xuan Su, Muhammad Ashraf, Il Man Kim, Neal L. Weintraub, Meng Jiang, Yaoliang Tang

Cardiology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Despite substantial advances in the development of medical and interventional strategies in ischemic and non-ischemic heart diseases, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Stem cell therapy for heart disease has gained traction over the past two decades and is an emerging option for the treatment of myocardial dysfunction. In this review, we summarize the current literature on different types of stem cells and their potential usage in ischemic and non-ischemic heart diseases. We emphasize the clinical utility of stem cells to improve myocardial structural and function, promote microvascular angiogenesis, and diminish scar size and major adverse cardiovascular events.We also discuss the therapeutic potential of microvesicles, such as exosomes, in the treatment of CVDs, which may open novel avenues for further clinical studies.

Original language	English (US)
Pages (from-to)	357-365
Number of pages	9
Journal	Journal of Cardiovascular Translational Research
Volume	11
Issue number	5
DOIs	https://doi.org/10.1007/s12265-018-9807-z
State	Published - Jan 1 2018

Keywords

Angiogenesis
Exosomes
Ischemic heart diseases
Microvesicles
Non-ischemic heart diseases
Stem cells

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmaceutical Science
Cardiology and Cardiovascular Medicine
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12265-018-9807-z

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title = "Regenerative therapy for cardiomyopathies",

abstract = "Despite substantial advances in the development of medical and interventional strategies in ischemic and non-ischemic heart diseases, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Stem cell therapy for heart disease has gained traction over the past two decades and is an emerging option for the treatment of myocardial dysfunction. In this review, we summarize the current literature on different types of stem cells and their potential usage in ischemic and non-ischemic heart diseases. We emphasize the clinical utility of stem cells to improve myocardial structural and function, promote microvascular angiogenesis, and diminish scar size and major adverse cardiovascular events.We also discuss the therapeutic potential of microvesicles, such as exosomes, in the treatment of CVDs, which may open novel avenues for further clinical studies.",

keywords = "Angiogenesis, Exosomes, Ischemic heart diseases, Microvesicles, Non-ischemic heart diseases, Stem cells",

author = "Zi Wang and Xuan Su and Muhammad Ashraf and Kim, {Il Man} and Weintraub, {Neal L.} and Meng Jiang and Yaoliang Tang",

note = "Funding Information: Funding This study was supported by the National Natural Science Foundation of China (nos. 81470391) and the National Natural Science Foundation of China (no. 81528002 to Y.T/Y.H). I. Kim, N.L. Weintraub, and Y. Tang were partially supported by the American Heart Association: GRNT31430008, NIH-AR070029, NIH-HL086555, NIH-HL134354, and NIH-HL12425. Funding Information: This study was supported by the National Natural Science Foundation of China (nos. 81470391) and the National Natural Science Foundation of China (no. 81528002 to Y.T/Y.H). I. Kim, N.L.Weintraub, and Y. Tang were partially supported by the American Heart Association: GRNT31430008, NIH-AR070029, NIH-HL086555, NIH-HL134354, and NIH-HL12425. Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2018.",

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AU - Su, Xuan

AU - Ashraf, Muhammad

AU - Kim, Il Man

AU - Weintraub, Neal L.

AU - Jiang, Meng

AU - Tang, Yaoliang

N1 - Funding Information: Funding This study was supported by the National Natural Science Foundation of China (nos. 81470391) and the National Natural Science Foundation of China (no. 81528002 to Y.T/Y.H). I. Kim, N.L. Weintraub, and Y. Tang were partially supported by the American Heart Association: GRNT31430008, NIH-AR070029, NIH-HL086555, NIH-HL134354, and NIH-HL12425. Funding Information: This study was supported by the National Natural Science Foundation of China (nos. 81470391) and the National Natural Science Foundation of China (no. 81528002 to Y.T/Y.H). I. Kim, N.L.Weintraub, and Y. Tang were partially supported by the American Heart Association: GRNT31430008, NIH-AR070029, NIH-HL086555, NIH-HL134354, and NIH-HL12425. Publisher Copyright: © Springer Science+Business Media, LLC, part of Springer Nature 2018.

PY - 2018/1/1

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N2 - Despite substantial advances in the development of medical and interventional strategies in ischemic and non-ischemic heart diseases, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Stem cell therapy for heart disease has gained traction over the past two decades and is an emerging option for the treatment of myocardial dysfunction. In this review, we summarize the current literature on different types of stem cells and their potential usage in ischemic and non-ischemic heart diseases. We emphasize the clinical utility of stem cells to improve myocardial structural and function, promote microvascular angiogenesis, and diminish scar size and major adverse cardiovascular events.We also discuss the therapeutic potential of microvesicles, such as exosomes, in the treatment of CVDs, which may open novel avenues for further clinical studies.

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Regenerative therapy for cardiomyopathies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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