TY - JOUR
T1 - Regulation of post-golgi traf fic of G protein-coupled receptors
AU - Wu, Guangyu
N1 - Funding Information:
This work was supported by National Institutes of Health Grant R01GM076167 (to G Wu).
Publisher Copyright:
© Springer Science+Business Media Dordrecht 2012.
PY - 2012/5/29
Y1 - 2012/5/29
N2 - Anterograde traf ficking of newly synthesized G protein-coupled receptors (GPCRs) from the endoplasmic reticulum to the cell surface represents a crucial checkpoint in controlling the amount of the functional receptors at the cell surface and the strength of signaling initiated by the receptors. In contrast to the extensively studied, well-understood endocytic and recycling pathways, the molecular mechanisms underlying the cell-surface targeting of the receptors remain poorly de fined. In this chapter, I will discuss current advances in understanding post-Golgi transport of GPCRs by focusing on speci fic motifs or sequences that may function as sorting signals regulating export from the Golgi and subsequent transport to the plasma membrane of GPCRs.
AB - Anterograde traf ficking of newly synthesized G protein-coupled receptors (GPCRs) from the endoplasmic reticulum to the cell surface represents a crucial checkpoint in controlling the amount of the functional receptors at the cell surface and the strength of signaling initiated by the receptors. In contrast to the extensively studied, well-understood endocytic and recycling pathways, the molecular mechanisms underlying the cell-surface targeting of the receptors remain poorly de fined. In this chapter, I will discuss current advances in understanding post-Golgi transport of GPCRs by focusing on speci fic motifs or sequences that may function as sorting signals regulating export from the Golgi and subsequent transport to the plasma membrane of GPCRs.
KW - Anterograde transport
KW - Cell-surface targeting
KW - G protein-coupled receptors
KW - Post-Golgi transport
KW - Small GTPases
KW - Sorting motifs
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U2 - 10.1007/978-94-007-4765-4_5
DO - 10.1007/978-94-007-4765-4_5
M3 - Article
C2 - 23161134
AN - SCOPUS:84889877914
SN - 0306-0225
VL - 63
SP - 83
EP - 95
JO - Subcellular Biochemistry
JF - Subcellular Biochemistry
ER -