TY - JOUR
T1 - Renal Epithelial Mitochondria
T2 - Implications for Hypertensive Kidney Disease
AU - Stadler, Krisztian
AU - Ilatovskaya, Daria V.
N1 - Publisher Copyright:
© American Physiological Society.
PY - 2024/1
Y1 - 2024/1
N2 - According to the Centers for Disease Control and Prevention, 1 in 2 U.S. adults have hypertension, and more than 1 in 7 chronic kidney disease. In fact, hypertension is the second leading cause of kidney failure in the United States; it is a complex disease characterized by, leading to, and caused by renal dysfunction. It is well-established that hypertensive renal damage is accompanied by mitochondrial damage and oxidative stress, which are differentially regulated and manifested along the nephron due to the diverse structure and functions of renal cells. This article provides a summary of the relevant knowledge of mitochondrial bioenergetics and metabolism, focuses on renal mitochondrial function, and discusses the evidence that has been accumulated regarding the role of epithelial mitochondrial bioenergetics in the development of renal tissue dysfunction in hypertension.
AB - According to the Centers for Disease Control and Prevention, 1 in 2 U.S. adults have hypertension, and more than 1 in 7 chronic kidney disease. In fact, hypertension is the second leading cause of kidney failure in the United States; it is a complex disease characterized by, leading to, and caused by renal dysfunction. It is well-established that hypertensive renal damage is accompanied by mitochondrial damage and oxidative stress, which are differentially regulated and manifested along the nephron due to the diverse structure and functions of renal cells. This article provides a summary of the relevant knowledge of mitochondrial bioenergetics and metabolism, focuses on renal mitochondrial function, and discusses the evidence that has been accumulated regarding the role of epithelial mitochondrial bioenergetics in the development of renal tissue dysfunction in hypertension.
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U2 - 10.1002/cphy.c220033
DO - 10.1002/cphy.c220033
M3 - Article
C2 - 38158371
AN - SCOPUS:85181416566
SN - 2040-4603
VL - 14
SP - 5225
EP - 5242
JO - Comprehensive Physiology
JF - Comprehensive Physiology
IS - 1
ER -