Reprint of "The role of cytoskeleton in the regulation of vascular endothelial barrier function" [Microvascular Research 76 (2008) 202-207]

Natalia V. Bogatcheva; Alexander D. Verin

doi:10.1016/S0026-2862(09)00021-1

Reprint of "The role of cytoskeleton in the regulation of vascular endothelial barrier function" [Microvascular Research 76 (2008) 202-207]

Natalia V. Bogatcheva, Alexander D. Verin

Pulmonary

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cell monolayer in quiescent endothelium, and to enable the disintegration of the formed barrier in response to various agonists. Vascular permeability is defined by the combination of transcellular and paracellular pathways, with the latter being a major contributor to the inflammation-induced barrier dysfunction. This review will analyze the cytoskeletal elements, which reorganization affects endothelial permeability, and emphasize signaling mechanisms with barrier-protective or barrier-disruptive potential.

Original language	English (US)
Pages (from-to)	64-69
Number of pages	6
Journal	Microvascular Research
Volume	77
Issue number	1
DOIs	https://doi.org/10.1016/S0026-2862(09)00021-1
State	Published - Jan 2009

Keywords

Barrier function
Cytoskeleton
Endothelial
Permeability

ASJC Scopus subject areas

Biochemistry
Cardiology and Cardiovascular Medicine
Cell Biology

Access to Document

10.1016/S0026-2862(09)00021-1

Cite this

@article{532419831464478f8343ddb8e1fbefff,

title = "Reprint of {"}The role of cytoskeleton in the regulation of vascular endothelial barrier function{"} [Microvascular Research 76 (2008) 202-207]",

abstract = "The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cell monolayer in quiescent endothelium, and to enable the disintegration of the formed barrier in response to various agonists. Vascular permeability is defined by the combination of transcellular and paracellular pathways, with the latter being a major contributor to the inflammation-induced barrier dysfunction. This review will analyze the cytoskeletal elements, which reorganization affects endothelial permeability, and emphasize signaling mechanisms with barrier-protective or barrier-disruptive potential.",

keywords = "Barrier function, Cytoskeleton, Endothelial, Permeability",

author = "Bogatcheva, {Natalia V.} and Verin, {Alexander D.}",

note = "Funding Information: This work was supported by grants from National Heart, Lung, and Blood Institutes, HL67307, HL80675, HL 083327 (ADV). ",

year = "2009",

month = jan,

doi = "10.1016/S0026-2862(09)00021-1",

language = "English (US)",

volume = "77",

pages = "64--69",

journal = "Microvascular Research",

issn = "0026-2862",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Reprint of "The role of cytoskeleton in the regulation of vascular endothelial barrier function" [Microvascular Research 76 (2008) 202-207]

AU - Bogatcheva, Natalia V.

AU - Verin, Alexander D.

N1 - Funding Information: This work was supported by grants from National Heart, Lung, and Blood Institutes, HL67307, HL80675, HL 083327 (ADV).

PY - 2009/1

Y1 - 2009/1

N2 - The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cell monolayer in quiescent endothelium, and to enable the disintegration of the formed barrier in response to various agonists. Vascular permeability is defined by the combination of transcellular and paracellular pathways, with the latter being a major contributor to the inflammation-induced barrier dysfunction. This review will analyze the cytoskeletal elements, which reorganization affects endothelial permeability, and emphasize signaling mechanisms with barrier-protective or barrier-disruptive potential.

AB - The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cell monolayer in quiescent endothelium, and to enable the disintegration of the formed barrier in response to various agonists. Vascular permeability is defined by the combination of transcellular and paracellular pathways, with the latter being a major contributor to the inflammation-induced barrier dysfunction. This review will analyze the cytoskeletal elements, which reorganization affects endothelial permeability, and emphasize signaling mechanisms with barrier-protective or barrier-disruptive potential.

KW - Barrier function

KW - Cytoskeleton

KW - Endothelial

KW - Permeability

UR - http://www.scopus.com/inward/record.url?scp=59849121672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59849121672&partnerID=8YFLogxK

U2 - 10.1016/S0026-2862(09)00021-1

DO - 10.1016/S0026-2862(09)00021-1

M3 - Article

C2 - 19232242

AN - SCOPUS:59849121672

SN - 0026-2862

VL - 77

SP - 64

EP - 69

JO - Microvascular Research

JF - Microvascular Research

IS - 1

ER -

Reprint of "The role of cytoskeleton in the regulation of vascular endothelial barrier function" [Microvascular Research 76 (2008) 202-207]

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this