Requirement for math5 in the development of retinal ganglion cells

Steven W. Wang, Byong Su Kim, Kan Ding, Huan Wang, Dantong Sun, Randy L. Johnson, William H. Klein, Lin Gan

Research output: Contribution to journalArticlepeer-review

398 Scopus citations


math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression of math5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5 blocks the initial differentiation of 80% of RGCs and results in an increase in differentiated amacrine cells. Furthermore, the absence of math5 abolishes the retinal expression of brn-3b and the formation of virtually all brn-3b-expressing RGCs. These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalGenes and Development
Issue number1
StatePublished - Jan 1 2001
Externally publishedYes


  • POU-domain
  • Retinal development
  • bHLH
  • brn-3b
  • math5

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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