Resident dendritic cell density in the lymph node paracortex is preDC-estined

Rafael S. Czepielewski; Gwendalyn J. Randolph

doi:10.1016/j.immuni.2023.07.013

Resident dendritic cell density in the lymph node paracortex is preDC-estined

Rafael S. Czepielewski, Gwendalyn J. Randolph

Physiology

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.

Original language	English (US)
Pages (from-to)	1699-1701
Number of pages	3
Journal	Immunity
Volume	56
Issue number	8
DOIs	https://doi.org/10.1016/j.immuni.2023.07.013
State	Published - Aug 8 2023

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.immuni.2023.07.013

Cite this

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title = "Resident dendritic cell density in the lymph node paracortex is preDC-estined",

abstract = "Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.",

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AU - Czepielewski, Rafael S.

AU - Randolph, Gwendalyn J.

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N2 - Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.

AB - Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.

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Resident dendritic cell density in the lymph node paracortex is preDC-estined

Abstract

ASJC Scopus subject areas

UN SDGs

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