An epidemiologic study was earned out to examine the possible role of β-agonists and other respiratory medications in the development of idiopathic dilated cardiomyopathy. Associations with respiratory medications, bronchial asthma, emphysema, and chronic bronchitis were examined by comparing newly diagnosed cases (n= 129) ascertained from five Washington, DC, area hospitals for the period 1990-1992 with neighborhood controls (n= 258) identified by using a random digit dialing technique. The cases and controls were matched on sex and 5-year age intervals and were compared in the analysis using conditional logistic regression methods. A statistically significant association was observed between idiopathic dilated cardiomyopathy and history of emphysema or chronic bronchitis (adjusted odds ratio (OR) = 4.4, 95% confidence interval (Cl) 1.6-12.4). The association with bronchial asthma was of borderline significance (adjusted OR = 1.9, 95% Cl 0.9-4.2). Associations were also observed with use of oral β-agonists (adjusted OR= 3.4, 95% Cl 1.1-11.0) and β-agonist inhalers or nebulization (adjusted OR = 3.2, 95% Cl 1.4-7.1), as well as with use of oral corticosteroids, inhaled corticosteroids or cromolyn, and theophylline medications. A total of 20.0% (23 of 115) of the cases had a reported history of β-agonist inhaler use compared with 6.7% (17 of 254) of the controls. The strength of these associations was diminished when the temporal relation between exposure to β-agonist inhalers or oral preparations and clinical diagnosis of idiopathic dilated cardiomyopathy was taken into account, however, and the associations with duration of β-agonist medication use were not statistically significant (p > 0.05). The results of this study suggest, but do not prove, that use of β-agonists has an etiologic role in idiopathic dilated cardiomyopathy.
|Original language||English (US)|
|Number of pages||9|
|Journal||American journal of epidemiology|
|State||Published - Aug 15 1995|
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