Review of intraurethral suppositories and iontophoresis therapy for erectile dysfunction

R. W. Lewis

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


This brief review examines the history of the intraurethral (IU) pharmacotherapy for the treatment of erectile dysfunction (ED). Emphasis is placed on the design, study endpoints and results of a limited number of clinical trials undertaken with PGE1-MUSE to demonstrate the efficacy of this unique delivery system. Next, the theory of the iontophoretic technique of drug delivery is discussed. Clinical data collected while applying these methods are presented, but are thus far limited to treatment of patients with Peyronie’s disease. Iontophoresis as a drug delivery alternative may gain popularity with ED patients who fail other types of therapy or in patients with other penile disorders.

Original languageEnglish (US)
Pages (from-to)S86-S90
JournalInternational journal of impotence research
StatePublished - Oct 1 2000
Externally publishedYes


  • Electromotive drug delivery
  • International index of erectile function
  • Peyronie’s disease
  • Pharmacotherapy

ASJC Scopus subject areas

  • Urology


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