TY - JOUR
T1 - Risks for gestational diabetes mellitus and pregnancy-induced hypertension are increased in polycystic ovary syndrome
AU - Wang, Yunhui
AU - Zhao, Xiaomiao
AU - Zhao, Huidan
AU - Ding, Hong
AU - Tan, Jianping
AU - Chen, Jingte
AU - Zhang, Rui
AU - Azziz, Ricardo
AU - Yang, Dongzi
PY - 2013
Y1 - 2013
N2 - Objectives. To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS). Methods. Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined. Results. The incidence of GDM was notably higher among all PCOS combined (54.9%; OR: 2.9, 95% CI: 2.0-4.1) and PCOS subgroups, whether they conceived spontaneously (51.5%; OR: 3.3, 95% CI: 2.0-5.4), or via IVF-ET or ovarian stimulation, compared with controls (14.3%; P < 0.001). The incidence of PIH was also higher among all PCOS (10.4%; OR: 2.2, 95% CI: 1.1-4.4) and the subgroup conceiving spontaneously (11.8%; OR: 2.6, 95% CI: 1.1-6.2; P < 0.001) but not for those conceiving with IVF-ET (9.1%) or ovarian stimulation (9.4%). Lean women with PCOS (BMI < 24 kg/m2) had higher incidences of GDM (51.1% versus 14.5%; OR: 5.6, 95% CI: 3.4-9.0) and PIH (8.9% versus 3.2%; OR: 3.0, 95% CI: 1.3-7.1) than lean controls. PCOS woemn with normal glucose tolerance had higher risk for PIH than their comparable control group (OR: 4.0, 95% CI: 1.3-11.7). Conclusion. This study suggested that PCOS is an independent risk factor for the development of GDM and PIH. This trial is registered with ChiCTR-RCC-11001824.
AB - Objectives. To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS). Methods. Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined. Results. The incidence of GDM was notably higher among all PCOS combined (54.9%; OR: 2.9, 95% CI: 2.0-4.1) and PCOS subgroups, whether they conceived spontaneously (51.5%; OR: 3.3, 95% CI: 2.0-5.4), or via IVF-ET or ovarian stimulation, compared with controls (14.3%; P < 0.001). The incidence of PIH was also higher among all PCOS (10.4%; OR: 2.2, 95% CI: 1.1-4.4) and the subgroup conceiving spontaneously (11.8%; OR: 2.6, 95% CI: 1.1-6.2; P < 0.001) but not for those conceiving with IVF-ET (9.1%) or ovarian stimulation (9.4%). Lean women with PCOS (BMI < 24 kg/m2) had higher incidences of GDM (51.1% versus 14.5%; OR: 5.6, 95% CI: 3.4-9.0) and PIH (8.9% versus 3.2%; OR: 3.0, 95% CI: 1.3-7.1) than lean controls. PCOS woemn with normal glucose tolerance had higher risk for PIH than their comparable control group (OR: 4.0, 95% CI: 1.3-11.7). Conclusion. This study suggested that PCOS is an independent risk factor for the development of GDM and PIH. This trial is registered with ChiCTR-RCC-11001824.
UR - http://www.scopus.com/inward/record.url?scp=84893812979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893812979&partnerID=8YFLogxK
U2 - 10.1155/2013/182582
DO - 10.1155/2013/182582
M3 - Article
C2 - 24371816
AN - SCOPUS:84893812979
SN - 2314-6133
VL - 2013
JO - BioMed Research International
JF - BioMed Research International
M1 - 182582
ER -