Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics

Joo Sung Kim; Jiaqi Li; If H.A. Barnes; David A. Baltzegar; Mohanasundari Pajaniappan; Thomas W. Cullen; M. Stephen Trent; Christopher M. Burns; Stuart A Thompson

doi:10.1128/JB.00765-08

Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics

Joo Sung Kim, Jiaqi Li, If H.A. Barnes, David A. Baltzegar, Mohanasundari Pajaniappan, Thomas W. Cullen, M. Stephen Trent, Christopher M. Burns, Stuart A Thompson

Infectious Disease

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The Δcj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type.

Original language	English (US)
Pages (from-to)	6524-6529
Number of pages	6
Journal	Journal of Bacteriology
Volume	190
Issue number	19
DOIs	https://doi.org/10.1128/JB.00765-08
State	Published - Oct 2008

ASJC Scopus subject areas

Microbiology
Molecular Biology

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title = "Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics",

abstract = "Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The Δcj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type.",

author = "Kim, {Joo Sung} and Jiaqi Li and Barnes, {If H.A.} and Baltzegar, {David A.} and Mohanasundari Pajaniappan and Cullen, {Thomas W.} and Trent, {M. Stephen} and Burns, {Christopher M.} and Thompson, {Stuart A}",

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AU - Kim, Joo Sung

AU - Li, Jiaqi

AU - Barnes, If H.A.

AU - Baltzegar, David A.

AU - Pajaniappan, Mohanasundari

AU - Cullen, Thomas W.

AU - Trent, M. Stephen

AU - Burns, Christopher M.

AU - Thompson, Stuart A

PY - 2008/10

Y1 - 2008/10

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AB - Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The Δcj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type.

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JO - Journal of Bacteriology

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ER -

Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics

Abstract

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