ROS mediate proapoptotic and antisurvival activity of oleanane triterpenoid cddo-me in ovarian cancer cells

Keyphrases

• Annexin V 20%
• Anti-apoptotic 40%
• Anti-apoptotic Agent 20%
• Anti-apoptotic Proteins 20%
• Antiproliferative Activity 40%
• Antitumor Activity 20%
• Apoptosis-inducing Activity 20%
• B-cell Lymphoma 2 (Bcl-2) 40%
• Caspase-3 20%
• CDDO-Me 100%
• Cell Proliferation Inhibition 20%
• Cyano 20%
• Cytokine-induced Apoptosis Inhibitor 1 40%
• Downmodulation 20%
• Fluorescein Isothiocyanate 20%
• Hydrogen Peroxide 20%
• Large B-cell Lymphoma 40%
• Mammalian Target of Rapamycin (mTOR) 40%
• Methyl 20%
• Mitochondrial Membrane Potential 20%
• N-acetylcysteine 80%
• Nuclear factor-κB 40%
• Nuclear factor-κB p65 20%
• Oleanane Triterpenoid 100%
• Ovarian Cancer Cells 100%
• PARP Inhibitor (PARPi) 20%
• Phospho-Akt 20%
• Pro-apoptotic 100%
• Pro-survival 40%
• Reactive Oxygen Species 100%
• Reactive Oxygen Species Production 40%
• Signaling Molecules 40%
• Survivin 40%

Pharmacology, Toxicology and Pharmaceutical Science

• Antiapoptotic 50%
• Antitumor Activity 16%
• B Cell Lymphoma 66%
• Baculoviral IAP Repeat Containing Protein 3 33%
• Bardoxolone 33%
• Bardoxolone Methyl 100%
• Fluorescein Isothiocyanate 16%
• Hydrogen Peroxide 16%
• Immunoglobulin Enhancer Binding Protein 50%
• Lipocortin 5 16%
• Mammalian Target of Rapamycin 16%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 1 16%
• Ovary Cancer 100%
• Procaspase 3 16%
• Reactive Oxygen Metabolite 100%
• Survivin 33%
• Triterpenoid 100%