Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice

Keyphrases

• Functional Outcome 100%
• Traumatic Brain Injury 100%
• Neuroprotective 100%
• Senolytic Therapy 100%
• Senescent Cells 33%
• Senolytics 33%
• Recognition Memory 25%
• Neurodegeneration 16%
• Hippocampus 16%
• P21Cip1 16%
• P16INK4a 16%
• Depressive-like Behavior 16%
• Controlled Cortical Impact 16%
• Senescence-associated Secretory Phenotype 16%
• Posterior Thalamus 16%
• Cortex 8%
• Interleukin-6 8%
• Astrocytes 8%
• Microglia 8%
• Ablation 8%
• Corpus Callosum 8%
• Mouse Model 8%
• Reduced Expression 8%
• Interleukin-1β 8%
• Cerebral Cortex 8%
• Drug Treatment 8%
• Cell Markers 8%
• Reference Memory 8%
• Ablating 8%
• Spatial Reference Memory 8%
• Behavioral Tests 8%
• Inflammatory Factors 8%
• Long-term Functional Outcome 8%
• Number of Neurons 8%
• Quercetin 8%
• Dasatinib 8%
• Chronic Neuroinflammation 8%
• Memory Behavior 8%
• Reference Recognition 8%
• Intermittent Administration 8%

Neuroscience

• Neuroprotective Agent 100%
• Neurotrauma 100%
• Traumatic Brain Injury 100%
• Behavior (Neuroscience) 16%
• Neurodegeneration 16%
• Hippocampus 16%
• Recognition Memory 16%
• Reference Memory 16%
• Thalamus 16%
• Cerebral Cortex 8%
• Astrocyte 8%
• Microglia 8%
• Corpus Callosum 8%
• Interleukin 6 8%
• Interleukin 1 8%
• Behavioral Test 8%
• Quercetin 8%
• Dasatinib 8%

Medicine and Dentistry

• Neuroprotective Agent 100%
• Traumatic Brain Injury 100%
• Injury 16%
• Hippocampus 16%
• Thalamus 16%
• Neurodegeneration 16%
• Reference Memory 16%
• Drug Therapy 8%
• Corpus Callosum 8%
• Emergency Medical Technician 8%
• Interleukin 1 8%
• Cell Marker 8%
• Microglia 8%
• Catheter Ablation 8%
• Astrocyte 8%
• Interleukin 6 8%
• Dasatinib 8%
• Cerebral Cortex 8%
• Neuroinflammation 8%
• Quercetin 8%