TY - JOUR
T1 - Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone Influence Muscle Outcomes in Children and Adolescents
AU - Wright, Christian S.
AU - Laing, Emma M.
AU - Pollock, Norman K.
AU - Hausman, Dorothy B.
AU - Weaver, Connie M.
AU - Martin, Berdine R.
AU - McCabe, George P.
AU - Peacock, Munro
AU - Warden, Stuart J.
AU - Hill Gallant, Kathleen M.
AU - Lewis, Richard D.
N1 - Funding Information:
This study was supported by NIH NICHD grant HD057126 (PI: RDL) and USDA, CSRS, National Institute of Food and Agriculture Hatch projects GEO00797 (PI: RDL), and GEO00798 (PI: EML). Clinical Trials registration number: NCT00931580.
Funding Information:
We thank Ms Ruth Gildea Taylor and Ms Jessica Smith for their overall coordination of this project, Dr Ashley Ferrira for her technical assistance, and the participants and their families for their commitment to furthering research. This study was supported by NIH NICHD grant HD057126 (PI: RDL) and USDA, CSRS, National Institute of Food and Agriculture Hatch projects GEO00797 (PI: RDL), and GEO00798 (PI: EML). Clinical Trials registration number: NCT00931580. Authors? roles: RDL, CMW, EML, NKP, GPM, MP, and STW conceived and designed the experiment. RDL, CMW, EML, NKP, MP, STW, DBH, BRM, KHG, and CSW conducted the study and collected data. CSW, RDL, and GPM were involved in data analysis and interpretation. CSW and RDL wrote the manuscript and all authors provided editorial input, as well as read and gave final approval for the manuscript. CSW takes responsibility for the integrity of the data analysis.
Publisher Copyright:
© 2018 American Society for Bone and Mineral Research
PY - 2018/11
Y1 - 2018/11
N2 - Increases in 25-hydroxyvitamin D concentrations are shown to improve strength in adults; however, data in pediatric populations are scant and equivocal. In this ancillary study of a larger-scale, multi-sited, double-blind, randomized, placebo-controlled vitamin D intervention in US children and adolescents, we examined the associations between changes in vitamin D metabolites and changes in muscle mass, strength, and composition after 12 weeks of vitamin D3 supplementation. Healthy male and female, black and white children and adolescents between the ages of 9 and 13 years from two US states (Georgia 34°N and Indiana 40°N) were enrolled in the study and randomly assigned to receive an oral vitamin D3 dose of 0, 400, 1000, 2000, or 4000 IU/d for 12 weeks between the winter months of 2009 to 2011 (N = 324). Analyses of covariance, partial correlations, and regression analyses of baseline and 12-week changes (post-baseline) in vitamin D metabolites (serum 25(OH)D, 1,25(OH)2D, intact parathyroid hormone [iPTH]), and outcomes of muscle mass, strength, and composition (total body fat-free soft tissue [FFST], handgrip strength, forearm and calf muscle cross-sectional area [MCSA], muscle density, and intermuscular adipose tissue [IMAT]) were assessed. Serum 25(OH)D and 1,25(OH)2D, but not iPTH, increased over time, as did fat mass, FFST, forearm and calf MCSA, forearm IMAT, and handgrip strength (p < 0.05). Vitamin D metabolites were not associated with muscle strength at baseline nor after the 12-week intervention. Changes in serum 25(OH)D correlated with decreases in forearm IMAT, whereas changes in serum iPTH predicted increases in forearm and calf MCSA and IMAT (p < 0.05). Overall, increases in 25(OH)D did not influence muscle mass or strength in vitamin D-sufficient children and adolescents; however, the role of iPTH on muscle composition in this population is unknown and warrants further investigation.
AB - Increases in 25-hydroxyvitamin D concentrations are shown to improve strength in adults; however, data in pediatric populations are scant and equivocal. In this ancillary study of a larger-scale, multi-sited, double-blind, randomized, placebo-controlled vitamin D intervention in US children and adolescents, we examined the associations between changes in vitamin D metabolites and changes in muscle mass, strength, and composition after 12 weeks of vitamin D3 supplementation. Healthy male and female, black and white children and adolescents between the ages of 9 and 13 years from two US states (Georgia 34°N and Indiana 40°N) were enrolled in the study and randomly assigned to receive an oral vitamin D3 dose of 0, 400, 1000, 2000, or 4000 IU/d for 12 weeks between the winter months of 2009 to 2011 (N = 324). Analyses of covariance, partial correlations, and regression analyses of baseline and 12-week changes (post-baseline) in vitamin D metabolites (serum 25(OH)D, 1,25(OH)2D, intact parathyroid hormone [iPTH]), and outcomes of muscle mass, strength, and composition (total body fat-free soft tissue [FFST], handgrip strength, forearm and calf muscle cross-sectional area [MCSA], muscle density, and intermuscular adipose tissue [IMAT]) were assessed. Serum 25(OH)D and 1,25(OH)2D, but not iPTH, increased over time, as did fat mass, FFST, forearm and calf MCSA, forearm IMAT, and handgrip strength (p < 0.05). Vitamin D metabolites were not associated with muscle strength at baseline nor after the 12-week intervention. Changes in serum 25(OH)D correlated with decreases in forearm IMAT, whereas changes in serum iPTH predicted increases in forearm and calf MCSA and IMAT (p < 0.05). Overall, increases in 25(OH)D did not influence muscle mass or strength in vitamin D-sufficient children and adolescents; however, the role of iPTH on muscle composition in this population is unknown and warrants further investigation.
KW - MUSCLE COMPOSITION
KW - MUSCLE HEALTH
KW - PARATHYROID HORMONE
KW - PEDIATRICS
KW - VITAMIN D
UR - http://www.scopus.com/inward/record.url?scp=85053208449&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053208449&partnerID=8YFLogxK
U2 - 10.1002/jbmr.3550
DO - 10.1002/jbmr.3550
M3 - Article
C2 - 30001469
AN - SCOPUS:85053208449
SN - 0884-0431
VL - 33
SP - 1940
EP - 1947
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
IS - 11
ER -
