Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape from Combination Monoclonal Antibody Treatment in a Person with HIV

Dara Khosravi; Hannah Soloff; Rose M. Langsjoen; Andrei Bombin; Colleen F. Kelley; Susan M. Ray; Clifford J. Gunthel; Brian C. Zanoni; Phuong Vi Nguyen; Jesse J. Waggoner; Yun F. Wang; Valeria D. Cantos; Anne Piantadosi

doi:10.1093/ofid/ofad054

Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape from Combination Monoclonal Antibody Treatment in a Person with HIV

Dara Khosravi, Hannah Soloff, Rose M. Langsjoen, Andrei Bombin, Colleen F. Kelley, Susan M. Ray, Clifford J. Gunthel, Brian C. Zanoni, Phuong Vi Nguyen, Jesse J. Waggoner, Yun F. Wang, Valeria D. Cantos, Anne Piantadosi

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.

Original language	English (US)
Article number	ofad054
Journal	Open Forum Infectious Diseases
Volume	10
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofad054
State	Published - Feb 1 2023
Externally published	Yes

Keywords

HIV
immunocompromised
monoclonal antibody
SARS-CoV-2
virus evolution

ASJC Scopus subject areas

Oncology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Khosravi, D., Soloff, H., Langsjoen, R. M., Bombin, A., Kelley, C. F., Ray, S. M., Gunthel, C. J., Zanoni, B. C., Nguyen, P. V., Waggoner, J. J., Wang, Y. F., Cantos, V. D., & Piantadosi, A. (2023). Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape from Combination Monoclonal Antibody Treatment in a Person with HIV. Open Forum Infectious Diseases, 10(2), Article ofad054. https://doi.org/10.1093/ofid/ofad054

Khosravi, D, Soloff, H, Langsjoen, RM, Bombin, A, Kelley, CF, Ray, SM, Gunthel, CJ, Zanoni, BC, Nguyen, PV, Waggoner, JJ, Wang, YF, Cantos, VD & Piantadosi, A 2023, 'Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape from Combination Monoclonal Antibody Treatment in a Person with HIV', Open Forum Infectious Diseases, vol. 10, no. 2, ofad054. https://doi.org/10.1093/ofid/ofad054

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abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.",

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AU - Kelley, Colleen F.

AU - Ray, Susan M.

AU - Gunthel, Clifford J.

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AU - Nguyen, Phuong Vi

AU - Waggoner, Jesse J.

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AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.

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Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape from Combination Monoclonal Antibody Treatment in a Person with HIV

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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