Sida rhomboidea.Roxb leaf extract ameliorates gentamicin induced nephrotoxicity and renal dysfunction in rats

Ethnopharmacological relevance: Sida rhomboidea.Roxb (SR) known as " Mahabala" in Ayurveda and marketed as " Shahadeyi" is used in ethnomedicine to treat ailments such as dysuria and urinary disorders. Aim of the study: To evaluate nephroprotective potential of SR against gentamicin (GM) induced nephrotoxicity and renal dysfunction. Materials and methods: Nephrotoxicity was induced in rats with GM (100. mg/kg bodyweight (i.p.) for 8 days) and were treated with SR extract (200 and 400. mg/kg bodyweight (p.o.) for 8 days) or 0.5% carboxymethyl cellulose (vehicle). Plasma and urine urea and creatinine, renal enzymatic and non-enzymatic antioxidants along with lipid peroxidation were evaluated in various experimental groups. Results: GM treatment induced significant elevation (p< 0.05) in plasma and urine urea, creatinine, renal lipid peroxidation along with significant decrement (p< 0.05) in renal enzymatic and non-enzymatic antioxidants. SR treatment to GM treated rats (GM. +. SR) recorded significant decrement (p< 0.05) in plasma and urine urea and creatinine, renal lipid peroxidation along with significant increment (p< 0.05) in renal enzymatic and non-enzymatic antioxidants. Conclusion: SR leaf extract ameliorates GM induced nephrotoxicity and renal dysfunction and thus validates its ethnomedicinal use.