TY - JOUR
T1 - Significance of HIV status in cervical cancer patients receiving curative chemoradiation therapy, definitive radiation alone, or palliative radiation in Botswana
AU - Meghani, Kinza
AU - Puri, Priya
AU - Bazzett-Matabele, Lisa
AU - Vuylsteke, Peter
AU - Luckett, Rebecca
AU - Monare, Barati
AU - Chiyapo, Sebathu
AU - Ketlametswe, Rebecca
AU - Ralefala, Tlotlo B.
AU - Bvochora-Nsingo, Memory
AU - Zetola, Nicola
AU - Ramogola-Masire, Doreen
AU - Grover, Surbhi
N1 - Publisher Copyright:
© 2024 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.
PY - 2024
Y1 - 2024
N2 - BACKGROUND: Cervical cancer associated with human papillomavirus has the highest cancer incidence and mortality for women in Botswana because of a high HIV prevalence and limited screening. This study investigates the significance of HIV on the overall survival (OS) of patients with locally advanced cervical cancer by various treatment categories (curative chemoradiation, definitive radiation [RT] alone, or palliative RT alone). METHODS: This study included patients diagnosed with cervical cancer between 2013 and 2020, prospectively enrolled in the Botswana Prospective Cancer Cohort. OS based on HIV status and completion of planned treatment regimen was estimated by the Kaplan–Meier method. Comparisons of 2-year OS by HIV status was performed by the log-rank test, univariate and multivariable Cox analyses adjusting for cancer stage, RT dose, number of chemotherapy cycles, and baseline hemoglobin levels. RESULTS: Of 1131 patients diagnosed with stage IB-IVB cervical cancer, 69.8% were women living with HIV (n = 789). For patients receiving curative chemoradiation, HIV status was not significantly associated with OS in unadjusted (p =.987) and adjusted (p =.578) analyses. For RT only treatment and definitive (high-dose) RT alone, HIV status was significantly associated with OS in unadjusted analysis (HR = 1.77, p =.002; HR = 1.95, p =.014), but not in adjusted analysis (p =.227, p =.73). For patients receiving palliative (low-dose) RT, HIV status was not associated with OS in unadjusted (p =.835) or adjusted analysis (p =.359). CONCLUSIONS: In Botswana, a resource-limited setting, HIV status had no significant effect on 2-year OS in patients with cervical cancer with well-managed HIV receiving chemoradiation, RT alone, or palliative RT. This demonstrates that patients living with HIV receiving antiretroviral treatment can receive clinically appropriate treatment with no evidence that HIV may lead to poorer outcomes.
AB - BACKGROUND: Cervical cancer associated with human papillomavirus has the highest cancer incidence and mortality for women in Botswana because of a high HIV prevalence and limited screening. This study investigates the significance of HIV on the overall survival (OS) of patients with locally advanced cervical cancer by various treatment categories (curative chemoradiation, definitive radiation [RT] alone, or palliative RT alone). METHODS: This study included patients diagnosed with cervical cancer between 2013 and 2020, prospectively enrolled in the Botswana Prospective Cancer Cohort. OS based on HIV status and completion of planned treatment regimen was estimated by the Kaplan–Meier method. Comparisons of 2-year OS by HIV status was performed by the log-rank test, univariate and multivariable Cox analyses adjusting for cancer stage, RT dose, number of chemotherapy cycles, and baseline hemoglobin levels. RESULTS: Of 1131 patients diagnosed with stage IB-IVB cervical cancer, 69.8% were women living with HIV (n = 789). For patients receiving curative chemoradiation, HIV status was not significantly associated with OS in unadjusted (p =.987) and adjusted (p =.578) analyses. For RT only treatment and definitive (high-dose) RT alone, HIV status was significantly associated with OS in unadjusted analysis (HR = 1.77, p =.002; HR = 1.95, p =.014), but not in adjusted analysis (p =.227, p =.73). For patients receiving palliative (low-dose) RT, HIV status was not associated with OS in unadjusted (p =.835) or adjusted analysis (p =.359). CONCLUSIONS: In Botswana, a resource-limited setting, HIV status had no significant effect on 2-year OS in patients with cervical cancer with well-managed HIV receiving chemoradiation, RT alone, or palliative RT. This demonstrates that patients living with HIV receiving antiretroviral treatment can receive clinically appropriate treatment with no evidence that HIV may lead to poorer outcomes.
KW - Botswana
KW - HIV
KW - cervical cancer
KW - chemoradiation
KW - outcomes
KW - palliative
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U2 - 10.1002/cncr.35289
DO - 10.1002/cncr.35289
M3 - Article
C2 - 38529676
AN - SCOPUS:85189563144
SN - 0008-543X
JO - Cancer
JF - Cancer
ER -