Site specific properties of carious dentin matrices biomodified with collagen cross-linkers

Ana K. Bedran-Russo, Sachin Karol, David H. Pashley, Grace Viana

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Purpose: To assess in non-cavitated carious teeth the mechanical properties of dentin matrix by measuring its reduced modulus of elasticity and the effect of dentin biomodification strategies on three dentin matrix zones: caries-affected, apparently normal dentin below caries-affected zone and sound dentin far from carious site. Methods: Nano-indentations were performed on dentin matrices of carious molars before and after surface modification using known cross-linking agents (glutaraldehyde, proanthocyanidins from grape seed extract and carbodiimide). Results: Statistically significant differences were observed between dentin zones of demineralized dentin prior to surface biomodification (P< 0.05). Following surface modification, there were no statistically significant differences between dentin zones (P< 0.05). An average increase of 30-fold, 2-fold and 2.2-fold of the reduced modulus of elasticity was observed following treatments of the three dentin zones with proanthocyanidin, carbodiimide and glutaraldehyde, respectively.

Original languageEnglish (US)
Pages (from-to)244-248
Number of pages5
JournalAmerican journal of dentistry
Issue number5
StatePublished - Oct 2013

ASJC Scopus subject areas

  • General Dentistry


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