Spectrophotometric determination of verapamil hydrochloride in drug formulations with chloramine-T as oxidant

Nafisur Rahman; MD Nasrul Hoda

doi:10.1007/s00216-002-1521-6

Spectrophotometric determination of verapamil hydrochloride in drug formulations with chloramine-T as oxidant

Nafisur Rahman, MD Nasrul Hoda

Medical Laboratory, Imaging and Radiologic Sciences

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A new spectrophotometric method is described for the determination of verapamil hydrochloride, based on its oxidation with chloramine-T in hydrochloric acid medium. It produces a yellow colored compound with maximum absorbance at 425 nm. Beer's law was obeyed in the concentration range 0-340 μg mL^-1 with molar absorptivity 2×10³ L mol^-1 cm^-1 and RSD 0.3-0.82%. All variables were studied to optimize the reaction conditions. No interferences were observed from the common excipients present in the formulations. The method has been applied successfully to the determination of the drug in pharmaceutical preparations. Statistical comparison of the results with those from the reference method reveals excellent agreement and confirms that accuracy and precision are not significantly different.

Original language	English (US)
Pages (from-to)	484-489
Number of pages	6
Journal	Analytical and Bioanalytical Chemistry
Volume	374
Issue number	3
DOIs	https://doi.org/10.1007/s00216-002-1521-6
State	Published - Oct 16 2002

Keywords

Chloramine-T
Pharmaceutical formulations
Spectrophotometry
Verapamil hydrochloride

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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10.1007/s00216-002-1521-6

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title = "Spectrophotometric determination of verapamil hydrochloride in drug formulations with chloramine-T as oxidant",

abstract = "A new spectrophotometric method is described for the determination of verapamil hydrochloride, based on its oxidation with chloramine-T in hydrochloric acid medium. It produces a yellow colored compound with maximum absorbance at 425 nm. Beer's law was obeyed in the concentration range 0-340 μg mL-1 with molar absorptivity 2×103 L mol-1 cm-1 and RSD 0.3-0.82%. All variables were studied to optimize the reaction conditions. No interferences were observed from the common excipients present in the formulations. The method has been applied successfully to the determination of the drug in pharmaceutical preparations. Statistical comparison of the results with those from the reference method reveals excellent agreement and confirms that accuracy and precision are not significantly different.",

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AU - Rahman, Nafisur

AU - Hoda, MD Nasrul

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N2 - A new spectrophotometric method is described for the determination of verapamil hydrochloride, based on its oxidation with chloramine-T in hydrochloric acid medium. It produces a yellow colored compound with maximum absorbance at 425 nm. Beer's law was obeyed in the concentration range 0-340 μg mL-1 with molar absorptivity 2×103 L mol-1 cm-1 and RSD 0.3-0.82%. All variables were studied to optimize the reaction conditions. No interferences were observed from the common excipients present in the formulations. The method has been applied successfully to the determination of the drug in pharmaceutical preparations. Statistical comparison of the results with those from the reference method reveals excellent agreement and confirms that accuracy and precision are not significantly different.

AB - A new spectrophotometric method is described for the determination of verapamil hydrochloride, based on its oxidation with chloramine-T in hydrochloric acid medium. It produces a yellow colored compound with maximum absorbance at 425 nm. Beer's law was obeyed in the concentration range 0-340 μg mL-1 with molar absorptivity 2×103 L mol-1 cm-1 and RSD 0.3-0.82%. All variables were studied to optimize the reaction conditions. No interferences were observed from the common excipients present in the formulations. The method has been applied successfully to the determination of the drug in pharmaceutical preparations. Statistical comparison of the results with those from the reference method reveals excellent agreement and confirms that accuracy and precision are not significantly different.

KW - Chloramine-T

KW - Pharmaceutical formulations

KW - Spectrophotometry

KW - Verapamil hydrochloride

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Spectrophotometric determination of verapamil hydrochloride in drug formulations with chloramine-T as oxidant

Abstract

Keywords

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