Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion

Keyphrases

• Mitochondrial Function 100%
• SphK2 100%
• Hepatic Ischemia-reperfusion Injury 100%
• Sphingosine-1-phosphate 40%
• Ischemia-reperfusion Injury 30%
• Mitochondrial Permeability Transition 30%
• Inflammation 20%
• Cell Death 20%
• Mitochondrial Dysfunction 20%
• Reperfusion 20%
• Phosphate Levels 20%
• Liver Injury 20%
• Mitochondrial Depolarization 20%
• Cultured Hepatocytes 20%
• Transition Onset 20%
• ABC294640 20%
• Inducible Nitric Oxide Synthase 10%
• Small Interfering RNA (siRNA) 10%
• New Targets 10%
• Liver 10%
• Neutrophil Infiltration 10%
• Hepatocytes 10%
• Before Surgery 10%
• Selective Inhibitor 10%
• Warm Ischemia 10%
• Calcein 10%
• Inflammation Response 10%
• Mouse Survival 10%
• Anoxia-reoxygenation 10%
• Hepatocyte Death 10%

Biochemistry, Genetics and Molecular Biology

• Reperfusion 100%
• Sphingosine Kinase 100%
• Hepatocyte 40%
• Sphingosine-1-Phosphate 40%
• Messenger RNA 30%
• Mitochondrial Permeability 30%
• Mouse 20%
• Cell Death 20%
• Nitric Oxide Synthase 10%
• Tumor Necrosis Factor 10%
• Neutrophil Chemotaxis 10%
• Small Interfering RNA 10%
• Calcein 10%
• Reoxygenation 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Liver Ischemia 100%
• Sphingosine Kinase 2 100%
• Sphingosine 1 Phosphate 40%
• Inflammation 30%
• Ischemia 30%
• Mouse 20%
• Liver Injury 20%
• Opaganib 20%
• Tumor Necrosis Factor 10%
• Inducible Nitric Oxide Synthase 10%
• Reperfusion Injury 10%
• Small Interfering RNA 10%
• Calcein 10%
• Anoxia 10%