STAT3 as a therapeutic target for Epstein-Barr virus (EBV) - associated nasopharyngeal carcinoma

Yeung Ho; Sai Wah Tsao; Musheng Zeng; Vivian Wai Yan Lui

doi:10.1016/j.canlet.2012.11.052

STAT3 as a therapeutic target for Epstein-Barr virus (EBV) - associated nasopharyngeal carcinoma

Yeung Ho, Sai Wah Tsao, Musheng Zeng, Vivian Wai Yan Lui

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Nasopharyngeal carcinoma (NPC), an endemic head and neck cancer found in Southeast Asia, is etiologically associated with the infection of an oncogenic virus, the Epstein-Barr virus (EBV). Here, we review literature findings on the potential/putative role of STAT3 signaling in its pathogenesis and discuss anti-STAT3 targeting as a therapeutic and possibly prevention strategy for NPC. Lastly, the potential involvement of STAT3 in other oncovirus-associated (e.g. the human papillomavirus) head and neck cancers have not been investigated and we hope that findings in EBV-associated NPC can prompt future investigations in these cancers, which are of increasing impact in the Western countries.

Original language	English (US)
Pages (from-to)	141-149
Number of pages	9
Journal	Cancer Letters
Volume	330
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2012.11.052
State	Published - Apr 28 2013
Externally published	Yes

Keywords

EBV
Head and neck cancers
Molecular targeting
Nasopharyngeal cancer
STAT3

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2012.11.052

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title = "STAT3 as a therapeutic target for Epstein-Barr virus (EBV) - associated nasopharyngeal carcinoma",

abstract = "Nasopharyngeal carcinoma (NPC), an endemic head and neck cancer found in Southeast Asia, is etiologically associated with the infection of an oncogenic virus, the Epstein-Barr virus (EBV). Here, we review literature findings on the potential/putative role of STAT3 signaling in its pathogenesis and discuss anti-STAT3 targeting as a therapeutic and possibly prevention strategy for NPC. Lastly, the potential involvement of STAT3 in other oncovirus-associated (e.g. the human papillomavirus) head and neck cancers have not been investigated and we hope that findings in EBV-associated NPC can prompt future investigations in these cancers, which are of increasing impact in the Western countries.",

keywords = "EBV, Head and neck cancers, Molecular targeting, Nasopharyngeal cancer, STAT3",

author = "Yeung Ho and Tsao, {Sai Wah} and Musheng Zeng and Lui, {Vivian Wai Yan}",

note = "Funding Information: VWYL is supported by the Patricia L. Knebel Fund of the Pittsburgh Foundation, USA, the Career Development Program of the Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer (5P50 CA097190-05), the Head and Neck Cancer SPORE Developmental Research Award (5P50 CA097007). SWT received funding support from the Hong Kong General Research Fund (HKU 770809M, HKU776608M, HKU779810M and HKI780911M), the AoE NPC grant (AoE/M-06/08), and RCG Grant from University of Hong Kong. MZ is supported by National Natural Science Foundation of China (81025014 and 81161120408).",

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doi = "10.1016/j.canlet.2012.11.052",

language = "English (US)",

volume = "330",

pages = "141--149",

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AU - Ho, Yeung

AU - Tsao, Sai Wah

AU - Zeng, Musheng

AU - Lui, Vivian Wai Yan

N1 - Funding Information: VWYL is supported by the Patricia L. Knebel Fund of the Pittsburgh Foundation, USA, the Career Development Program of the Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer (5P50 CA097190-05), the Head and Neck Cancer SPORE Developmental Research Award (5P50 CA097007). SWT received funding support from the Hong Kong General Research Fund (HKU 770809M, HKU776608M, HKU779810M and HKI780911M), the AoE NPC grant (AoE/M-06/08), and RCG Grant from University of Hong Kong. MZ is supported by National Natural Science Foundation of China (81025014 and 81161120408).

PY - 2013/4/28

Y1 - 2013/4/28

N2 - Nasopharyngeal carcinoma (NPC), an endemic head and neck cancer found in Southeast Asia, is etiologically associated with the infection of an oncogenic virus, the Epstein-Barr virus (EBV). Here, we review literature findings on the potential/putative role of STAT3 signaling in its pathogenesis and discuss anti-STAT3 targeting as a therapeutic and possibly prevention strategy for NPC. Lastly, the potential involvement of STAT3 in other oncovirus-associated (e.g. the human papillomavirus) head and neck cancers have not been investigated and we hope that findings in EBV-associated NPC can prompt future investigations in these cancers, which are of increasing impact in the Western countries.

AB - Nasopharyngeal carcinoma (NPC), an endemic head and neck cancer found in Southeast Asia, is etiologically associated with the infection of an oncogenic virus, the Epstein-Barr virus (EBV). Here, we review literature findings on the potential/putative role of STAT3 signaling in its pathogenesis and discuss anti-STAT3 targeting as a therapeutic and possibly prevention strategy for NPC. Lastly, the potential involvement of STAT3 in other oncovirus-associated (e.g. the human papillomavirus) head and neck cancers have not been investigated and we hope that findings in EBV-associated NPC can prompt future investigations in these cancers, which are of increasing impact in the Western countries.

KW - EBV

KW - Head and neck cancers

KW - Molecular targeting

KW - Nasopharyngeal cancer

KW - STAT3

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STAT3 as a therapeutic target for Epstein-Barr virus (EBV) - associated nasopharyngeal carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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