Stearic acid methyl ester affords neuroprotection and improves functional outcomes after cardiac arrest

Po Yi Chen; Celeste Yin Chieh Wu; Garrett A. Clemons; Cristiane T. Citadin; Alexandre Couto e Silva; Harlee E. Possoit; Rinata Azizbayeva; Nathan E. Forren; Chin Hung Liu; K. N.Shashanka Rao; David M. Krzywanski; Reggie Hui Chao Lee; Jake T. Neumann; Hung Wen Lin

doi:10.1016/j.plefa.2020.102138

Stearic acid methyl ester affords neuroprotection and improves functional outcomes after cardiac arrest

Po Yi Chen, Celeste Yin Chieh Wu, Garrett A. Clemons, Cristiane T. Citadin, Alexandre Couto e Silva, Harlee E. Possoit, Rinata Azizbayeva, Nathan E. Forren, Chin Hung Liu, K. N.Shashanka Rao, David M. Krzywanski, Reggie Hui Chao Lee, Jake T. Neumann, Hung Wen Lin

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Cardiac arrest causes neuronal damage and functional impairments that can result in learning/memory dysfunction after ischemia. We previously identified a saturated fatty acid (stearic acid methyl ester, SAME) that was released from the superior cervical ganglion (sympathetic ganglion). The function of stearic acid methyl ester is currently unknown. Here, we show that SAME can inhibit the detrimental effects of global cerebral ischemia (i.e. cardiac arrest). Treatment with SAME in the presence of asphyxial cardiac arrest (ACA) revived learning and working memory deficits. Similarly, SAME-treated hippocampal slices after oxygen-glucose deprivation inhibited neuronal cell death. Moreover, SAME afforded neuroprotection against ACA in the CA1 region of the hippocampus, reduced ionized calcium-binding adapter molecule 1 expression and inflammatory cytokines/chemokines, with restoration in mitochondria respiration. Altogether, we describe a unique and uncharted role of saturated fatty acids in the brain that may have important implications against cerebral ischemia.

Original language	English (US)
Article number	102138
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	159
DOIs	https://doi.org/10.1016/j.plefa.2020.102138
State	Published - Aug 2020
Externally published	Yes

Keywords

Asphyxial cardiac arrest (ACA)
Cerebral ischemia
Hippocampus
Long chain saturated fatty acid
Neuroinflammation
Neuroprotection
Stearic acid methyl ester (SAME)

ASJC Scopus subject areas

Clinical Biochemistry
Cell Biology

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10.1016/j.plefa.2020.102138

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Chen, P. Y., Wu, C. Y. C., Clemons, G. A., Citadin, C. T., Couto e Silva, A., Possoit, H. E., Azizbayeva, R., Forren, N. E., Liu, C. H., Rao, K. N. S., Krzywanski, D. M., Lee, R. H. C., Neumann, J. T., & Lin, H. W. (2020). Stearic acid methyl ester affords neuroprotection and improves functional outcomes after cardiac arrest. Prostaglandins Leukotrienes and Essential Fatty Acids, 159, Article 102138. https://doi.org/10.1016/j.plefa.2020.102138

Chen, PY, Wu, CYC, Clemons, GA, Citadin, CT, Couto e Silva, A, Possoit, HE, Azizbayeva, R, Forren, NE, Liu, CH, Rao, KNS, Krzywanski, DM, Lee, RHC, Neumann, JT & Lin, HW 2020, 'Stearic acid methyl ester affords neuroprotection and improves functional outcomes after cardiac arrest', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 159, 102138. https://doi.org/10.1016/j.plefa.2020.102138

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title = "Stearic acid methyl ester affords neuroprotection and improves functional outcomes after cardiac arrest",

abstract = "Cardiac arrest causes neuronal damage and functional impairments that can result in learning/memory dysfunction after ischemia. We previously identified a saturated fatty acid (stearic acid methyl ester, SAME) that was released from the superior cervical ganglion (sympathetic ganglion). The function of stearic acid methyl ester is currently unknown. Here, we show that SAME can inhibit the detrimental effects of global cerebral ischemia (i.e. cardiac arrest). Treatment with SAME in the presence of asphyxial cardiac arrest (ACA) revived learning and working memory deficits. Similarly, SAME-treated hippocampal slices after oxygen-glucose deprivation inhibited neuronal cell death. Moreover, SAME afforded neuroprotection against ACA in the CA1 region of the hippocampus, reduced ionized calcium-binding adapter molecule 1 expression and inflammatory cytokines/chemokines, with restoration in mitochondria respiration. Altogether, we describe a unique and uncharted role of saturated fatty acids in the brain that may have important implications against cerebral ischemia.",

keywords = "Asphyxial cardiac arrest (ACA), Cerebral ischemia, Hippocampus, Long chain saturated fatty acid, Neuroinflammation, Neuroprotection, Stearic acid methyl ester (SAME)",

author = "Chen, {Po Yi} and Wu, {Celeste Yin Chieh} and Clemons, {Garrett A.} and Citadin, {Cristiane T.} and {Couto e Silva}, Alexandre and Possoit, {Harlee E.} and Rinata Azizbayeva and Forren, {Nathan E.} and Liu, {Chin Hung} and Rao, {K. N.Shashanka} and Krzywanski, {David M.} and Lee, {Reggie Hui Chao} and Neumann, {Jake T.} and Lin, {Hung Wen}",

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year = "2020",

month = aug,

doi = "10.1016/j.plefa.2020.102138",

language = "English (US)",

volume = "159",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

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T1 - Stearic acid methyl ester affords neuroprotection and improves functional outcomes after cardiac arrest

AU - Chen, Po Yi

AU - Wu, Celeste Yin Chieh

AU - Clemons, Garrett A.

AU - Citadin, Cristiane T.

AU - Couto e Silva, Alexandre

AU - Possoit, Harlee E.

AU - Azizbayeva, Rinata

AU - Forren, Nathan E.

AU - Liu, Chin Hung

AU - Rao, K. N.Shashanka

AU - Krzywanski, David M.

AU - Lee, Reggie Hui Chao

AU - Neumann, Jake T.

AU - Lin, Hung Wen

PY - 2020/8

Y1 - 2020/8

N2 - Cardiac arrest causes neuronal damage and functional impairments that can result in learning/memory dysfunction after ischemia. We previously identified a saturated fatty acid (stearic acid methyl ester, SAME) that was released from the superior cervical ganglion (sympathetic ganglion). The function of stearic acid methyl ester is currently unknown. Here, we show that SAME can inhibit the detrimental effects of global cerebral ischemia (i.e. cardiac arrest). Treatment with SAME in the presence of asphyxial cardiac arrest (ACA) revived learning and working memory deficits. Similarly, SAME-treated hippocampal slices after oxygen-glucose deprivation inhibited neuronal cell death. Moreover, SAME afforded neuroprotection against ACA in the CA1 region of the hippocampus, reduced ionized calcium-binding adapter molecule 1 expression and inflammatory cytokines/chemokines, with restoration in mitochondria respiration. Altogether, we describe a unique and uncharted role of saturated fatty acids in the brain that may have important implications against cerebral ischemia.

AB - Cardiac arrest causes neuronal damage and functional impairments that can result in learning/memory dysfunction after ischemia. We previously identified a saturated fatty acid (stearic acid methyl ester, SAME) that was released from the superior cervical ganglion (sympathetic ganglion). The function of stearic acid methyl ester is currently unknown. Here, we show that SAME can inhibit the detrimental effects of global cerebral ischemia (i.e. cardiac arrest). Treatment with SAME in the presence of asphyxial cardiac arrest (ACA) revived learning and working memory deficits. Similarly, SAME-treated hippocampal slices after oxygen-glucose deprivation inhibited neuronal cell death. Moreover, SAME afforded neuroprotection against ACA in the CA1 region of the hippocampus, reduced ionized calcium-binding adapter molecule 1 expression and inflammatory cytokines/chemokines, with restoration in mitochondria respiration. Altogether, we describe a unique and uncharted role of saturated fatty acids in the brain that may have important implications against cerebral ischemia.

KW - Asphyxial cardiac arrest (ACA)

KW - Cerebral ischemia

KW - Hippocampus

KW - Long chain saturated fatty acid

KW - Neuroinflammation

KW - Neuroprotection

KW - Stearic acid methyl ester (SAME)

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M1 - 102138

ER -

Stearic acid methyl ester affords neuroprotection and improves functional outcomes after cardiac arrest

Abstract

Keywords

ASJC Scopus subject areas

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